Results 31 to 40 of about 3,389,488 (311)

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, C. Mihalcioiu, S. Rabbani
semanticscholar   +1 more source

Yersinia pestis Plasminogen Activator

Biomolecules, 2020
The Gram-negative bacterium Yersinia pestis causes plague, a fatal flea-borne anthropozoonosis, which can progress to aerosol-transmitted pneumonia. Y.
Florent Sebbane, Vladimir N. Uversky, Andrey P. Anisimov   +2 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy?

Women's Health, 2020
Background: Clinical factors associated with exclusion from recombinant tissue plasminogen activator in both men and women are not completely understood.
Oluyemi R Rotimi, Iretioluwa F Ajani, Alexandria Penwell, Shyyon Lari, Brittany Walker, Thomas I Nathaniel   +5 more
doaj   +1 more source

Successful Treatment of Arterial Thrombus in an Extremely Low-Birth-Weight Preterm Neonate

Pediatrics and Neonatology, 2013
Arterial thromboembolism in the pediatric population frequently occurs secondary to arterial catheterization. Catheterization-related complications are more common in smaller and sicker infants, due to high prothrombotic activity, low levels of natural ...
Petek G. Kayıran, Berkan Gürakan, Sinan M. Kayıran   +2 more
doaj   +1 more source

Reversal of cilioretinal artery occlusion with intra-arterial tissue plasminogen activator

American Journal of Ophthalmology Case Reports, 2017
Purpose: To present the reversal of a cilioretinal artery occlusion with the use of intra-arterial tissue plasminogen activator. Observations: A monocular 74 year old male presented with a cilioretinal artery occlusion.
Andrew J. McClellan, Harry W. Flynn, Jr., Eric C. Peterson, Norman J. Schatz   +3 more
doaj   +1 more source

Intravenous tissue plasminogen activator for ischemic stroke in early pregnancy dosed by actual body weight

SAGE Open Medical Case Reports, 2019
Introduction: Few published reports highlight intravenous tissue plasminogen activator use during the first trimester of pregnancy and provide outcomes for mother and fetus.
Gary D Peksa, Jamie Ostrem, Teresa Davis
doaj   +1 more source

Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients’ serum after SARS-CoV-2 infection

Frontiers in Cellular and Infection Microbiology, 2023
Severe acute respiratory syndrome coronavirus-2 causes hyperinflammation and activation of coagulation cascade and, as a result, aggravates endothelial cell dysfunction. N-acetylcysteine and Sulodexide have been found to mitigate endothelial damage.
Justyna Rajewska-Tabor, Patrycja Sosińska-Zawierucha, Malgorzata Pyda, Maciej Lesiak, Andrzej Bręborowicz, Andrzej Bręborowicz   +5 more
doaj   +1 more source

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

International Journal of Molecular Sciences, 2017
Normal pregnancy is a state of hypercoagulability with diminishing fibrinolytic activity, which is mainly caused by an increase of plasminogen activator inhibitor type 1 (PAI-1).
Y. Ye, A. Vattai, Xi Zhang, Junyan Zhu, C. Thaler, S. Mahner, U. Jeschke, V. von Schönfeldt   +7 more
semanticscholar   +1 more source

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

Circulation, 1987
Intravenous administration of 80 mg of recombinant tissue plasminogen activator (rt-PA, 40, 20, and 20 mg in successive hours) and streptokinase (SK, 1.5 million units over 1 hr) was compared in a double-blind, randomized trial in 290 patients with ...
J. Chesebro, G. Knatterud, R. Roberts, J. Borer, L. Cohen, J. Dalen, H. Dodge, C. Francis, D. Hillis, P. Ludbrook   +9 more
semanticscholar   +1 more source