Results 91 to 100 of about 180,408 (257)

A Heuristic Bayesian Approach to Knowledge Acquisition: Application to Analysis of Tissue-Type Plasminogen Activator [PDF]

arXiv, 2013
This paper describes a heuristic Bayesian method for computing probability distributions from experimental data, based upon the multivariate normal form of the influence diagram. An example illustrates its use in medical technology assessment. This approach facilitates the integration of results from different studies, and permits a medical expert to ...
arxiv  

Tumor markers in breast cancer - European Group on Tumor Markers recommendations [PDF]

, 2005
Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer.
Abraha RS, Andreasen PA, Arie van Dalen, ASCO Expert Panel, Barak V, Barnes DM, Baselga J, Bast RC, Benraad TH, Bieglmayer C, Blamey RW, Bonadonna G, Chan DW, Chebil G, Chu KC, Colditz G, Conneely OM, De Koning H, Devine PL, Dixon AR, Dnistrian AM, Dnistrian AM, Duffy MJ, Duffy MJ, Duffy MJ, Duffy MJ, Duffy MJ, Early Breast Cancer Trialist's, Early Breast Cancer Trialists Collaborative Group, Early Breast Cancer Trialists Collaborative Group, Easton DF, Ebeling FC, Ebeling FG, Eifel P, Einarsson R, Ekbom A, Elledge RM, Fisher B, Fitzgibbons PL, Gion M, Gion M, Guadagni F, Gyö, Harries M, Harvey JM, Helena Goike, Holli K, Holli K, Iwase H, Jager W, Jensen EV, Kamel EM, Konecny G, Kurebayashi J, Lamerz R, Leake R, Leers M, Leers MP, Leers MP, Legha SS, Leyland-Jones B, Look MP, Loomer L, Loprinzi CL, Madigan MP, Marius Nap, Massimo Gion, McCarty, McLaughlin R, Merimsky O, Michael J. Duffy, Mohsin SK, Molina R, Molina R, Molina R, Molina R, Molina R, Molina R, Molina R, Morrow M, Nakata B, Newcomb P, Nicolini A, Nicolini A, Nicolini A, O'Hanlon DM, Paik S, Palazzo S, Parker SL, Parkin DN, Pecking AP, Pertschuk LP, Pertschuk LP, Petra Stieber, Piccart MJ, Price MR, Rafael Molina, Robertson JFR, Robertson JFR, Rogers CE, Roland Einarsson, Rolf Lamerz, Romer M, Rosselli del Turco M, Safi F, Schapira DV, Schapira DV, Sjostrom J, Slamon D, Soletormos G, Soletormos G, Soletormos G, Soletormos G, Stieber P, Sturgeon CM, Sweep CGJ, Tabar L, The GIVIO, The GIVIO, Theriault RL, Thorpe SM, Tomlinson IP, Tondini C, Van Dalen A, Van Dalen A, van Dalen A, van Dalen A, Van Dalen A, van Dalen A, Veronesi U, Vivian Barak, Vizcarra E, Vyzula R, Weihua Z, Williams MR, Yamauchi H, Zucchelli GC   +136 more
core   +1 more source

Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis

Journal of Intensive Care, 2017
Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
doaj   +1 more source

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots [PDF]

arXiv, 2019
Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and severe side effects, including brain hemorrhage, associated with delayed administration.
arxiv  

Effect of valsartan on angiotensin II-induced plasminogen activator inhibitor-1 biosynthesis in arterial smooth muscle cells [PDF]

, 2001
Previous studies have shown that angiotensin II stimulates the synthesis of plasminogen activator inhibitor-1 in cultured vascular cells, which suggests that activation of the renin-angiotensin system may impair fibrinolysis.
A. Corsini, A. Parolari, A.M. Calvio, E. Tremoli, L. Arnaboldi, L. Mussoni, L. Sironi, M. de Gasparo   +7 more
core  

Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 83-97, January 2023., 2023
Abstract Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet‐induced obesity.
Bendik C. Brinchmann, Jørn A. Holme, Nadine Frerker, Mia H. Rambøl, Tommy Karlsen, Jan E. Brinchmann, Alena Kubátová, Klara Kukowski, Tonje Skuland, Johan Øvrevik   +9 more
wiley   +1 more source

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]

PLoS ONE, 2015
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White, Nuri M Kodaman, Reed H Harder, Folkert W Asselbergs, Douglas E Vaughan, Nancy J Brown, Jason H Moore, Scott M Williams   +7 more
doaj   +1 more source

Numerical study of cancer cell invasion dynamics using adaptive mesh refinement: the urokinase model [PDF]

arXiv, 2014
In the present work we investigate the chemotactically and proteolytically driven tissue invasion by cancer cells. The model employed is a system of advection-reaction-diffusion equations that features the role of the serine protease urokinase-type plasminogen activator.
arxiv  

Targeting the interaction of GABAB receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
There is no pharmacological treatment available to limit progressing neuronal death after cerebral ischemia. Here we show that targeting the interaction of GABAB receptors with CaMKII using a synthetic interfering peptide after an excitotoxic insult in cultured neurons or in brain slices from MCAO‐treated mice restored downregulated GABAB receptor ...
Karthik Balakrishnan, Mohammad Hleihil, Musadiq A. Bhat, Robert P. Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke   +7 more
wiley   +1 more source

Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells [PDF]

, 2007
Increased levels of urokinase-type plasminogen activator (uPA) are associated with shortened overall survival in ovarian cancer patients. Additionally, elevated levels of the serine protease inhibitor (serpin), plasminogen activator inhibitor-1 (PAI-1 ...
Beaulieu, Lea M., Carter, Jennifer C., Church, Frank C., Whitley, Brandi R.   +3 more
core   +2 more sources