Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment
European Journal of Clinical Investigation, Volume 55, Issue 7, July 2025.Inflammation in atherosclerotic cardiovascular disease. Residual inflammatory risk (RIR), defined by high‐sensitive C‐reactive protein (hsCRP) concentration of ≥2 mg/L, represents a strong predictor of future atherosclerotic cardiovascular disease (ASCVD) events. Although increased hsCRP values ≥2 mg/L might be detected in every three out of five ASCVD
Natalie Arnold, Wolfgang Koenig
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The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1 [PDF]
, 1999 Chaoting Liu +5 more
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Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.ABSTRACT Background A 7‐month‐old female spayed English Springer Spaniel (ESS) was evaluated for spontaneous hemoperitoneum. Hyperfibrinolysis was identified on thromboelastography. Hypothesis/Objectives To identify a genetic mutation causing congenital hyperfibrinolysis in the proband and evaluate the prevalence of the mutation in the ESS breed ...
Kelley Kilpatrick +7 more
wiley +1 more source
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor [PDF]
, 1998 W. Kees RODENBURG +3 more
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Interplay of integrins and selectins in metastasis
Molecular Oncology, Volume 19, Issue 6, Page 1582-1611, June 2025.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
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Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus) [PDF]
, 1997 C S Venter +10 more
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Advanced Science, Volume 12, Issue 21, June 5, 2025.Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin +15 more
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Processing of type 1 plasminogen activator inhibitor (PAI-1) into the regulated secretory pathway.
, 1994 Lourdes Gombau, Raymond R. Schleef
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LC‐MS/MS proteomics identifies plasma proteins related to cognition over 9‐year follow‐up
Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.Abstract INTRODUCTION This project identified plasma proteins predictive of cognitive decline across a robust neuropsychological protocol over a 9‐year period. METHODS Vanderbilt Memory and Aging Project participants (n = 336, 73 ± 7 years, 59% male, 87% non‐Hispanic White, 10% Black/African American) underwent blood draw for baseline plasma protein ...
Hailey A. Adegboye +19 more
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Requirements for Transforming Growth Factor-β Regulation of the Pro-α2(I) Collagen and Plasminogen Activator Inhibitor-1 Promoters [PDF]
, 1995 Enoch Chang, Howard Goldberg
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