Results 331 to 340 of about 399,723 (373)
Some of the next articles are maybe not open access.
Plasminogen activator inhibitor-1 modulates adipocyte differentiation
American Journal of Physiology-Endocrinology and Metabolism, 2006Increased plasminogen activator inhibitor-1 (PAI-1) is linked to obesity and insulin resistance. However, the functional role of PAI-1 in adipocytes is unknown. This study was designed to investigate effects and underlying mechanisms of PAI-1 on glucose uptake in adipocytes and on adipocyte differentiation. Using primary cultured adipocytes from PAI-1+/
Xiubin, Liang +9 more
openaire +2 more sources
Plasminogen activator inhibitor‐1 and diabetic nephropathy
Nephrology, 2005SUMMARY: Diabetic nephropathy is characterized by excessive accumulation of extracellular matrix (ECM) in the kidney. Decreased ECM degradation as well as increased ECM synthesis plays an important role in ECM remodeling that favours tissue fibrosis. Plasminogen activator (PA)/plasmin/PA inhibitor (PAI) system is involved in ECM degradation and PAI‐1 ...
Hi Bahl, Lee, Hunjoo, Ha
openaire +2 more sources
Plasminogen Activator Inhibitor-1 in Vascular Thrombosis
Current Drug Targets, 2007Thrombotic complications of vascular disease constitute the leading cause of morbidity and mortality in much of the developed world. Current drug therapies available to treat the thrombotic component of arterial and venous vascular complications remain limited.
Randal J, Westrick, Daniel T, Eitzman
openaire +2 more sources
Genetic Architecture of Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor-1
Seminars in Thrombosis and Hemostasis, 2008Important biochemical constituents of the fibrinolytic system include tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). In the current review, we aim to describe the genetic architecture of t-PA and PAI-1. Several genetic polymorphisms in the T-PA and PAI-1 gene have been found to be associated with t-PA and PAI-1 ...
Asselbergs, Folkert W. +5 more
openaire +3 more sources
Neutralization by Plasminogen Activator Inhibitor-1 of Mutants of Tissue Plasminogen Activator
Enzyme, 1988Deletion mutants of human tissue plasminogen activator (tPA) were expressed in Chinese hamster ovary cells. These cells had been transfected with genes that encoded tPA but included restriction sites that allowed the deletion of DNA encoding specific structural domains of the tPA molecule's heavy chain.
P W, Bergum, L A, Erickson
openaire +2 more sources
Fibrinolysis, 1994
Abstract The relationship between PAI activity, active PAI-1 concentration and whole PAI-1 concentration was determined in 180 plasma samples of unselected ambulant patients of the department of internal medicine. To exclude a release of platelet PAI-1 after blood sampling, different anticoagulants and temperatures of blood storage were tested.
G. Siegert, Th. Fritz, E. Runge
openaire +1 more source
Abstract The relationship between PAI activity, active PAI-1 concentration and whole PAI-1 concentration was determined in 180 plasma samples of unselected ambulant patients of the department of internal medicine. To exclude a release of platelet PAI-1 after blood sampling, different anticoagulants and temperatures of blood storage were tested.
G. Siegert, Th. Fritz, E. Runge
openaire +1 more source
Plasminogen activator inhibitor-1 and the kidney
American Journal of Physiology-Renal Physiology, 2002Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that was isolated 20 years ago. First recognized as an inhibitor of intravascular fibrinolysis, it is now evident that PAI-1 is a multifunctional protein with actions that may be dependent on or independent of its protease inhibitory effects.
openaire +2 more sources
Plasminogen activator inhibitor 1 in thrombotic disease
Current Opinion in Hematology, 1996Impaired fibrinolytic function, mainly due to an elevation of plasma plasminogen activator inhibitor 1 concentration, is a common finding in patients with thrombotic disease. In patients subjected to hip surgery, preoperatively increased levels of plasminogen activator inhibitor 1 seem to be predictive of postoperative deep venous thrombosis.
openaire +2 more sources
Plasminogen activator inhibitor 1 in human carcinoma tissues
International Journal of Cancer, 1991AbstractThe content of PAI‐1 was measured in carcinoma tissues from the stomach and colorectum divided macroscopically into 3 portions: the central part of the carcinoma, the marginal part of the carcinoma containing some normal mucosa, and the normal mucosa. Among these tissues, the highest levels of PAI‐1 antigen were found in the central part of the
N, Tanaka +5 more
openaire +2 more sources
Plasminogen Activator Inhibitor 1 and Atherothrombosis
Thrombosis and Haemostasis, 1993I, Juhan-Vague, M C, Alessi
openaire +2 more sources