Results 91 to 100 of about 213,023 (194)
Molecular Microbiology, EarlyView.Biochemical data on the isolated Na+/H+‐exchanging ATPase, PfATP4, from the malaria parasite are missing. Here, we expressed and purified the nucleotide and phosphate binding domains as a soluble protein and identified key residues by enzymatic characterization of generated point mutants.
Timo Beyer +3 more
wiley +1 more source
Medical and Veterinary Entomology, EarlyView.The fitness of Anopheles coluzzii mosquito lines (VK strain) selected for early and late egg hatching was compared with each other and a reference strain (Mopti). There was an observed increase in fitness in fecundity and survival among the late‐hatching lines, but no negative effects of selection on fecundity and adult survival were detected.
Emmanuel C. Ottih +3 more
wiley +1 more source
Life at new extremes: Integrating stress physiology and the bio‐exposome in the Anthropocene
Annals of the New York Academy of Sciences, EarlyView.We propose to expand the concept of extreme environments to encompass those that are profoundly altered by climate and global changes, highlight the critical role of stress resilience in understanding how the exposome interacts with intracellular processes (bio‐exposome) in wildlife, emphasize how such interactions are relevant to the human bio ...
David Costantini +3 more
wiley +1 more source
Photodynamic therapy of cancer‐associated infections
Photochemistry and Photobiology, EarlyView.Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley +1 more source
Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy
Transplant Infectious Disease, EarlyView.ABSTRACT Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ ...
Haya Hayek +8 more
wiley +1 more source
, 2006 Alive matter distinguishes itself from inanimate matter by actively maintaining a high degree of inhomogenous organisation. Information processing is quintessential to this capability.
Gunji, Yukio-Pegio +2 more
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A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum
ChemMedChem, Volume 20, Issue 11, June 2, 2025.This article presents the development of a first‐in‐class inhibitor targeting the bromodomain protein PfBDP1 in Plasmodium falciparum, the deadliest variant of the malaria‐causing Plasmodium parasites. Through structure‐based drug design, the inhibitor interactions were characterized via X‐ray crystallography and isothermal titration calorimetry ...
Marius Amann +10 more
wiley +1 more source
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
Engineering Reports, Volume 7, Issue 6, June 2025.ABSTRACT Co‐infections such as malaria and tuberculosis pose significant public health challenges, particularly in regions where both diseases are endemic. Despite the global burden of these infections, their combined transmission dynamics remain poorly understood, highlighting the importance of this study. We develop a comprehensive mathematical model
Benedict Celestine Agbata +7 more
wiley +1 more source