Results 91 to 100 of about 310,877 (350)
British Journal of Clinical Pharmacology, EarlyView.Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding +24 more
wiley +1 more source
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Nature, 2015 Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global ...
A. Mbengue +18 more
semanticscholar +1 more source
Chemistry &Biodiversity, EarlyView.Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida +8 more
wiley +1 more source
Libyan Journal of Medicine, 2008 Malaria is the leading cause of morbidity and mortality in Sub-Saharan Africa. One key strategic intervention is provision of early diagnosis and prompt effective treatment.
Qader SS, Njuguna J
doaj
La mitocondria en el género Plasmodium.
Biomédica: revista del Instituto Nacional de Salud, 2003 La mitocondria en las células eucarióticas juega un papel central en el metabolismo energético. En Plasmodium, la mitocondria se adapta morfológica y fisiológicamente a las condiciones metabólicas de sus hospederos.
César Segura, Silvia Blair
doaj +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas +10 more
wiley +1 more source
QSAR Analysis of Natural Lupeol Analogs as Antimalarial agents [PDF]
BIO Web of ConferencesMalaria is an infectious disease that affects millions of people caused by Plasmodium parasite. The growing Plasmodium resistance underscores existing antimalarial drugs and necessities novel antimalarial drugs with high efficiency. Lupeol is a naturally
Rajathei David Mary
doaj +1 more source
Batch Synthesis of Primaquine Diphosphate Anti‐Malarial Drug
Chemistry – A European Journal, EarlyView.According to the WHO, a child under the age of five dies every 2 minutes from malaria in Africa. It is therefore paramount that access and availability of anti‐malarial drugs must be improved. We report a process for the synthesis of Primaquine Diphosphate, where key intermediates were obtained in a much shorter reaction time compared to processes ...
Faith M. Akwi +2 more
wiley +1 more source
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
Nature Communications, 2015 The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this mechanism in Plasmodium falciparum. We
Jigang Wang +19 more
semanticscholar +1 more source