Results 121 to 130 of about 213,023 (194)

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

open access: yesChemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil   +4 more
wiley   +1 more source

Sustainable Synthesis of 1,2,3‐Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry

open access: yesChemSusChem, Volume 18, Issue 10, May 19, 2025.
Green triazoles: The first successful synthesis of 1,2,3‐triazoles using Cyrene as a biodegradable and non‐toxic solvent in click chemistry has been developed. This sustainable approach allows product isolation by simple precipitation in water, eliminating the need for organic solvent extractions and chromatographic purifications, thus minimizing waste
Andrea Citarella   +4 more
wiley   +1 more source

Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?

open access: yesThe FASEB Journal, Volume 39, Issue 9, 15 May 2025.
ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, and respiratory symptoms appearing 2–6 h after the consumption of mammalian ...
Rita Vaz‐Rodrigues, José de la Fuente
wiley   +1 more source

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