Results 121 to 130 of about 310,877 (350)

Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp.

open access: yesThe Journal of Pathology, EarlyView.
Abstract We hypothesized that variants in inflammasome‐related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria‐endemic region in northern Brazil, assessing whether specific functional single nucleotide variants (SNVs) in inflammasome genes ...
Vinicius NC Leal   +8 more
wiley   +1 more source

The Rough Guide to Monocytes in Malaria Infection

open access: yesFrontiers in Immunology, 2018
While half of the world's population is at risk of malaria, the most vulnerable are still children under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria parasites to the human host; but how Plasmodium interact with the
Amaya Ortega-Pajares   +1 more
doaj   +1 more source

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

open access: yesAntimicrobial Agents and Chemotherapy, 2018
The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development.
Christel Brunschwig   +47 more
semanticscholar   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

CONVENTIONAL AND MOLECULAR DETECTION OF PLASMODIUM IN HUMANS

open access: yesPakistan Journal of Agriculture, Agricultural Engineering & Veterinary Sciences, 2017
Conventional and molecular detection of plasmodium, causative agent of malaria was carried out, during 2014-15 aiming at comparing the sensitivity of both the protocols. For conventional diagnosis, thin blood smear from 50 malaria suspected victims from
S. N. Panhwar   +4 more
doaj  

Nanoparticle‐Based Tetracycline Delivery Systems: Advancing Therapeutic Effectiveness and Tackling Antibiotic Resistance

open access: yesParticle &Particle Systems Characterization, EarlyView.
This review explores improved tetracycline (TCN) delivery via polymer‐based nanocarriers to enhance solubility, stability, and targeted release. It also covers stimuli‐responsive systems, triggered by pH, enzymes, or reactive oxygen species (ROS), and co‐delivery approaches that increase therapeutic efficacy in cancer and inflammatory diseases ...
Mahsa Molaei Nasr   +5 more
wiley   +1 more source

Structure and function based design of Plasmodium-selective proteasome inhibitors

open access: yesNature, 2016
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation. Compounds that target the proteasome are potentially valuable tools for the treatment of pathogens that depend ...
Hao Li   +9 more
semanticscholar   +1 more source

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