Glucocorticoid dysfunction in children with severe malaria
Frontiers in Immunology, 2023 IntroductionMalaria remains a widespread health problem with a huge burden. Severe or complicated malaria is highly lethal and encompasses a variety of pathological processes, including immune activation, inflammation, and dysmetabolism.
Leen Vandermosten +12 more
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Midgut microbiota of the malaria mosquito vector Anopheles gambiae and Interactions with plasmodium falciparum Infection [PDF]
, 2012 The susceptibility of Anopheles mosquitoes to Plasmodium infections relies on complex interactions between the insect vector and the malaria parasite.
A Chao +94 more
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A microsporidian impairs Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes
Nature Communications, 2020 A possible malaria control approach involves the dissemination in mosquitoes of inherited symbiotic microbes to block Plasmodium transmission. However, in the Anopheles gambiae complex, the primary African vectors of malaria, there are limited reports of
J. Herren +13 more
semanticscholar +1 more source
eLife, 2019 The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts.
Daniel M Parker +12 more
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Frontiers in Microbiology, 2023 IntroductionMalaria transmission occurs when Plasmodium sporozoites are transferred from the salivary glands of anopheline mosquitoes to a human host through the injection of saliva. The need for better understanding, as well as novel modes of inhibiting,
Anastasia Accoti +11 more
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Indels, structural variation, and recombination drive genomic diversity inPlasmodium falciparum [PDF]
, 2016 The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is ...
Campino, Susana +21 more
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The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
Science, 2019 Mapping the malaria parasite Several species of the parasite Plasmodium cause human malarial diseases, and, despite determined control efforts, a huge global disease burden remains. Howick et al. present a single-cell analysis of transcription across the
Virginia M. Howick +15 more
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The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design [PDF]
Open Biology, 2014 Merozoite surface protein 1 (MSP1) has been identified as a target antigen for protective immune responses against asexual blood stage malaria, but effective vaccines based on MSP1 have not been developed so far.
Rachel D. Curd +5 more
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Frontiers in Tropical Diseases, 2023 IntroductionIt is well known that dietary changes have a significant impact on the immune system, and modifications in lipid balance may contribute to disease progression in several cases.
Sara Malaguti Andrade Soares +4 more
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Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate +4 more
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