Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry
Angewandte Chemie, EarlyView.This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou +4 more
wiley +2 more sources
Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis
PLoS Pathogens, 2020 New techniques for obtaining electron microscopy data through the cell volume are being increasingly utilized to answer cell biologic questions. Here, we present a three-dimensional atlas of Plasmodium falciparum ultrastructure throughout parasite cell ...
Rachel M. Rudlaff +3 more
semanticscholar +1 more source
La mitocondria en el género Plasmodium.
Biomédica: revista del Instituto Nacional de Salud, 2003 La mitocondria en las células eucarióticas juega un papel central en el metabolismo energético. En Plasmodium, la mitocondria se adapta morfológica y fisiológicamente a las condiciones metabólicas de sus hospederos.
César Segura, Silvia Blair
doaj +1 more source
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]
, 2014 Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag +62 more
core +3 more sources
Emerging Topics in Life Sciences, 2017 Plasmodium falciparum is a protozoan parasite that causes the most severe form of human malaria. Five other Plasmodium species can also infect humans — P. vivax, P. malariae, P. ovale curtisi, P. ovale wallikeri and P. knowlesi — but P. falciparum is the most prevalent Plasmodium species in the African region, where 90% of all malaria occurs, and it is
openaire +2 more sources
A review on malaria eradication: what hope for Nigeria?
Journal of Applied Sciences and Environmental Management, 2016 Malaria and its transmitting vectors are household names. Malaria which helped Africa from the venomous fangs of colonialism has turned to be the bane of development in tropical countries including Nigeria.
E.C. Amadi
doaj +1 more source
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]
, 2017 BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel +8 more
core +1 more source
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
New England Journal of Medicine, 2016 BACKGROUND Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P.
D. Ménard +88 more
semanticscholar +1 more source
Neutrophils in malaria: A double-edged sword role
Frontiers in Immunology, 2022 Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first line of defense against invading foreign pathogens and might play a crucial role in malaria.
Kehinde Adebayo Babatunde +2 more
doaj +1 more source
Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift [PDF]
, 2014 <b>Background</b> Understanding of malaria pathogenesis caused by Plasmodium falciparum has been greatly deepened since the introduction of in vitro culture system, but the lack of a method to enrich ring-stage parasites remains a technical ...
Chan, Sherwin +5 more
core +1 more source