Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core +2 more sources
Genetic Analysis and Species Specific Amplification of the Artemisinin Resistance-Associated Kelch Propeller Domain in P. falciparum and P. vivax. [PDF]
Plasmodium falciparum resistance to artemisinin has emerged in the Greater Mekong Subregion and now poses a threat to malaria control and prevention. Recent work has identified mutations in the kelch propeller domain of the P.
Eldin Talundzic+7 more
doaj +1 more source
The duration of Plasmodium falciparum infections [PDF]
Plasmodium vivax et Plasmodium ovale sont souvent considérés comme les parasites du paludisme les mieux adaptés à la survie à long terme chez l'hôte humain en raison de leurs formes exo-érythrocytaires latentes. L'opinion dominante jusqu'au milieu du siècle dernier était que la durée maximale des infections à Plasmodium falciparum était inférieure à ...
Nicholas J. White+3 more
openaire +4 more sources
RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]
Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L+2 more
core +3 more sources
Plasmodium falciparum infection and the risk of anemia in school children
BACKGROUND According to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum ...
Suriyani Tan+2 more
doaj +1 more source
Prevalence of Clinical Artesunate Resistance among Cases of Complicated Malaria in Southern Odisha, India [PDF]
Introduction: Drug resistant malaria represents the most challenging health problem worldwide. The major threat to malaria control is the increasing incidence of complicated and drug-resistant cases.
Sindhusuta Das, Sanghamitra Padhi
doaj +1 more source
GAMETOCYTEMIA IN PLASMODIUM VIVAX AND PLASMODIUM FALCIPARUM INFECTIONS [PDF]
Two expert research microscopists, each blinded to the other's reports, diagnosed single-species malaria infections in 2,141 adults presenting at outpatient malaria clinics in Tak Province, Thailand, and Iquitos, Peru, in May-August 1998, May-July 1999, and May-June 2001.
Jeeraphat Sirichaisinthop+15 more
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MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Brothers, Robert C+10 more
core +2 more sources
Malaria adalah penyakit kronis dan akut yang disebabkan oleh protozoa dari jenis Plasmodium. Ada 4 spesies yang utama dari jenis plasmodium yang menyebabkan penyakit malaria pada manusia, yaitu: Plasmodium falciparum, Plasmodium vivax, Plasmodium ...
Nur Ain Banyal+2 more
doaj +1 more source
Malária grave por Plasmodium falciparum [PDF]
Malaria is one of the world's leading parasitic diseases and affects a considerably large number of people. Considering the epidemiological reach of Plasmodium falciparum, which is almost always responsible for the most severe cases of malaria, a discussion of the clinical features and therapeutic interventions is important.
Gomes, Andréia Patrícia+5 more
openaire +4 more sources