Results 51 to 60 of about 73,258 (213)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Chemical genetics of Plasmodium falciparum [PDF]

Nature, 2010
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose
Guiguemde, W Armand, Shelat, Anang A, Bouck, David, Duffy, Sandra, Crowther, Gregory J, Davis, Paul H, Smithson, David C, Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jimenez-Diaz, Maria B, Martinez, Maria S, Wilson, Emily B, Tripathi, Abhai K, Gut, Jiri, Sharlow, Elizabeth R, Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Inigo, Ferrer, Santiago, Rosenthal, Philip J, DeRisi, Joseph L, Sullivan, David J, Lazo, John S, Roos, David S, Riscoe, Michael K, Phillips, Margaret A, Rathod, Pradipsinh K, Van Voorhis, Wesley C, Avery, Vicky M, Guy, R Kiplin   +34 more
openaire   +4 more sources

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

KLASIFIKASI PERKEMBANGBIAKAN PLASMODIUM PENYEBAB PENYAKIT MALARIA DALAM SEL DARAH MERAH MANUSIA DENGAN MENGGUNAKAN SUPPORT VECTOR MACHINE (SVM) DI KOTA JAYAPURA-PAPUA

Ilkom Jurnal Ilmiah, 2018
Malaria adalah penyakit yang ditularkan oleh nyamuk dari manusia dan hewan lain yang disebabkan oleh protozoa parasite (sekelompok mikroorganisme bersel tunggal) dalam tipe Plasmodium.
Abd. Rachman Dayat, Nur Ain Banyal
doaj   +1 more source

Finding genes in Plasmodium falciparum [PDF]

Nature, 2000
The completion of the sequencing of chromosome 3 of the malarial parasite Plasmodium falciparum1 is a major step forward in our understanding of the Plasmodium genome. We have analysed this chromosome using GlimmerM, a freely available gene-finder developed specifically for the P. falciparum species2. GlimmerM was highly effective in finding nearly all
M, Pertea, S L, Salzberg, M J, Gardner
openaire   +2 more sources

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source