Results 71 to 80 of about 113,438 (254)

Antibodies to the glutamate dehydrogenase of Plasmodium falciparum [PDF]

, 1986
Polyclonal antisera raised against Plasmodium knowlesi reacted with NADP-specific glutamate dehydrogenase (GLDH) of P. knowlesi, GLDH of P. falciparum and GLDH of Proteus spp. The antisera did not react with NAD(P) GLDH from bovine liver.
Cooksley, S, Wilson, R J, Hempelmann, E, Ling, I T, Bates, P A   +4 more
core  

Performance of Microscopy for the Diagnosis of Malaria and Human African Trypanosomiasis by Diagnostic Laboratories in the Democratic Republic of the Congo: Results of a Nation-Wide External Quality Assessment. [PDF]

PLoS ONE, 2016
The present External Quality Assessment (EQA) assessed microscopy of blood parasites among diagnostic laboratories in the Democratic Republic of the Congo. The EQA addressed 445 participants in 10/11 provinces (October 2013-April 2014). Participants were
Pierre Mukadi, Veerle Lejon, Barbara Barbé, Philippe Gillet, Christophe Nyembo, Albert Lukuka, Joris Likwela, Crispin Lumbala, Justin Mbaruku, Wim Vander Veken, Dieudonné Mumba, Pascal Lutumba, Jean-Jacques Muyembe, Jan Jacobs   +13 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine. [PDF]

, 2011
Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further
Ishag Adam, Amal Gadalla, El-Sayed, Badria B., El-Sayed, Badria B, Nahla B. Gadalla, Sahar Bashir, Mukhtar, Izdihar, Sutherland, Colin J, David Warhurst, Gadalla, Amal, Mary Oguike, Fathi Mansour, Bashir, Sahar, Colin J. Sutherland, Izdihar Mukhtar, Elzaki, Salah-Eldin, Sutherland, Colin J., Gadalla, Nahla B, Badria B. El-Sayed, Oguike, Mary, Mansour, Fathi, Adam, Ishag, Warhurst, David, Salah-Eldin Elzaki, Gadalla, Nahla B.   +24 more
core   +1 more source

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source

Finding genes in Plasmodium falciparum [PDF]

Nature, 2000
The completion of the sequencing of chromosome 3 of the malarial parasite Plasmodium falciparum1 is a major step forward in our understanding of the Plasmodium genome. We have analysed this chromosome using GlimmerM, a freely available gene-finder developed specifically for the P. falciparum species2. GlimmerM was highly effective in finding nearly all
M, Pertea, S L, Salzberg, M J, Gardner
openaire   +2 more sources

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Identification and analysis of "Plasmodium falciparum" genes mediating cytoadherence [PDF]

, 1999
Malaria is the most important parasitic disease of man: almost two billion people live in areas in which the most pathogenic human Plasmodium species is transmitted. The parasite P.
Degen, Roland
core   +1 more source