Results 61 to 70 of about 170,206 (238)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

PNAS plus: plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state [PDF]

, 2012
The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this ...
Baertl, Bozdech, Brennand, C. Doerig, C. Fennell, Callebaut, Codd, D. E. Goldberg, Daily, Dever, Divo, Dyer, E. S. Istvan, Fennell, Fidock, Francis, Functional Genomics Workshop Group, Harris, Hinnebusch, Hinnebusch, Kafsack, Kilberg, Kim, Kourtis, L. Altenhofen, Lambros, Llinas, Lu, Lu, M. Llinas, Olszewski, Payne, Pfaller, Roth, Russo, S. A. Cobbold, S. E. Babbitt, Sharma, Sherman, Sims, Soeters, Towbin, Trager, van Werven, Wek, Zaborske, Zolg   +46 more
core   +1 more source

An Unfolding Story: AlphaFold's View on Protein Flexibility

Helvetica Chimica Acta, EarlyView.
AlphaFold confidence measures allow for detailed proteome‐wide characterization of protein flexibility. All flexibility measures increased substantially in the evolutionary transition from prokaryota to eukaryota. ABSTRACT The AlphaFold confidence measures are related to conformation distribution of the protein.
Gunnar Jeschke
wiley   +1 more source

Inactivation of Plasmodium falciparum in whole blood by riboflavin plus irradiation.

, 2013
BACKGROUND: Malaria parasites are frequently transmitted by unscreened blood transfusions in Africa. Pathogen reduction methods in whole blood would thus greatly improve blood safety.
Allain, Jean-Pierre, Atwal, Sharan, Dinko, Bismarck, El Chaar, Mira, Freimanis, Graham L, Sutherland, Colin J   +5 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Reliability of Rapid Diagnostic Tests in Diagnosing Pregnancy-Associated Malaria in North-Eastern Tanzania. [PDF]

, 2012
Accurate diagnosis and prompt treatment of pregnancy-associated malaria (PAM) are key aspects in averting adverse pregnancy outcomes. Microscopy is the gold standard in malaria diagnosis, but it has limited detection and availability.
A Mayor, A Moody, A Muehlenbachs, A Salanti, AA Adegnika, Adrian JF Luty, AE Mnzava, AHD Kilian, AJ Umbers, Ali Salanti, AM de Oliveira, B Mmbando, C Wongsrichanalai, Caroline Pehrson, CE Shulman, CE Shulman, Christentze Schmiegelow, D Ishengoma, Daniel Andersen, Daniel TR Minja, Davis John, DP Mason, DR Bell, DRS Ishengoma, E Tjitra, F Bánhidy, F Mockenhaupt, FP Mockenhaupt, FP Mockenhaupt, G Snounou, H Reyburn, H Verhoef, HL Guyatt, IA McGregor, J Baker, J Lusingu, J Wooden, JM Tham, John PA Lusingu, JP Lusingu, JR Forney, K Källander, KA Bojang, LC Okell, LEG Mboera, LM Singer, M Amexo, M Dhorda, M Fried, M Fried, M Mayxay, M Mayxay, Martha Lemnge, Mayke Oesterholt, Michael Alifrangis, ML McMorrow, N Othnigué, NEER Singh, NJ White, P Bejon, P Mens, P Mens, Pamela A Magistrado, PE Duffy, Philippe Deloron, R Bǿdker, RW Steketee, S Gerstl, S Karl, S Schachterle, Stéphanie Boström, T Jelinek, TA VanderJagt, The United Republic of Tanzania, Thor Theander, TT Thomsen, V Batwala, WHO   +77 more
core   +2 more sources

The immune response to malaria in utero. [PDF]

, 2020
Malaria causes tremendous early childhood morbidity and mortality, providing an urgent impetus for the development of a vaccine that is effective in neonates.
Feeney, Margaret E
core   +1 more source

Plasmodium falciparum « toutankhamonensis » [PDF]

Bulletin de la Société de pathologie exotique, 2010
Alexandre le Grand, les empereurs Titus et Othon II, Alaric, Olivier Cromwell, les papes Gregoire V, Leon X, Sixte V, Urbain VII, Alexandre VI, Borgia, Dante Alighieri, Byron, Le Caravage, Fausto Coppi... A la liste des victimes celebres, reelles, presumees ou imaginaires du paludisme, les medias viennent d’ajouter Toutankhamon sans se poser de ...
openaire   +1 more source

Solar Geoengineering Effects on Malaria Transmission Risk in South Asia Under G6sulfur Scenario

International Journal of Climatology, EarlyView.
Comparison of EIR (unit: No of infected bites per person per day) for each considered country in South Asia, under the considered scenarios, averaged over the period 2020–2090. A regression equation is shown for each country (for Bhutan EIRG = 0.1690 × 10−10 EIRS + 0.5968 × 10−12) to illustrate the projected trend.
Athar Hussain, Muhammad Ali Khan, Muhammad Shoaib   +2 more
wiley   +1 more source