Results 91 to 100 of about 73,258 (213)

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

Deconstruction of Aspartic Protease Inhibitors Enables Fragment‐Based Discovery of Plasmepsin V Inhibitors

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova, Laura Ruduša, Diana Zelencova‐Gopejenko, Aigars Jirgensons, Raitis Bobrovs   +4 more
wiley   +1 more source

Intra-individual variability in ancient plasmodium DNA recovery highlights need for enhanced sampling

Scientific Reports
Malaria has been a leading cause of death in human populations for centuries and remains a major public health challenge in African countries, especially affecting children. Among the five Plasmodium species infecting humans, Plasmodium falciparum is the
Alejandro Llanos-Lizcano, Michelle Hämmerle, Alessandra Sperduti, Susanna Sawyer, Brina Zagorc, Kadir Toykan Özdoğan, Meriam Guellil, Olivia Cheronet, Martin Kuhlwilm, Ron Pinhasi, Pere Gelabert   +10 more
doaj   +1 more source

Chronic Infection by Plasmodium falciparum

Cureus
Malaria by Plasmodium falciparum (P. falciparum) usually does not exceed one year, but chronic infection, although rare, is a possibility. We present the clinical case of a 37-year-old male who came to the emergency department with intermittent fever, chills, and malaise. He had malaria more than 1 year ago while working in Huíla province, Angola.
Manata, José Pedro, Brochado, Marisa, Silva, Bernardo, Chinchila, Jessenia, Matos Costa, João   +4 more
openaire   +2 more sources

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies

Chirality, Volume 38, Issue 8, August 2026.
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Amanda Mohr, Gustavo Machado das Neves, Érika Segala, Vera Lucia Eifler‐Lima, Martin Steppe   +4 more
wiley   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Estimating Causal Effects of Malaria Infection on Anaemia Among Children Under Five Years in Uganda: Evidence From a Cross‐Sectional Malaria Indicator Survey

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Malaria and anemia remain major public health challenges contributing substantially to morbidity and mortality among children under 5 years in sub‐Saharan Africa (SSA). Although conventional regression analyses have reported a significant association between malaria infection and anemia, these approaches often inadequately ...
Edson Mwebesa, Delight Mawufemor Agbi, Lameck Ondieki Agasa, Susan Awor, Herbert Tafadzwa Kazonda, Abraham Isiaka Jimmy, Scholastique M. Merveille Essetcheou, Isaac Kipkosgei Tum, Gregory Kibet Kerich, Ann Mwangi   +9 more
wiley   +1 more source

Geostatistical Modelling and Web‐Based Mapping of Malaria Risks Among Children Under Five Years in Nigeria: Evidence From the 2021 Nigeria Malaria Indicator Survey

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Malaria is a critical public health concern in Nigeria with the country bearing an uneven burden of the disease. In Nigeria, malaria is one of the main causes of child mortality and despite all efforts to reduce malaria mortality rates, the disease remains a major concern, notably among children under‐fives.
Justice Moses K. Aheto, Bakare Emmanuel Afolabi, Dolapo O. Oniyelu, Deborah O. Daniel, Steven I. Ikediashi, Oluwaseun A. Mogbojuri, Ronke D. Olorunfemi, Sodiq A. Orogun, Afeez Abidemi, Idowu I. Olasupo, Samuel A. Osikoya, Samuel A. Adeyemi, Hapiness O. Ismail, Isaac Bakare, Samson O. Olagbami, Dolapo A. Bakare, Baiyeri Samuel, Temitayo V. Irewole, Oluwafunmilayo O. Olapade, Oluwafolakemi Odunola, Oghenekevwe R. Ajewole, Joshua P. Ojo, Segun Oyedeji, Wisdom Takramah   +23 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source