Results 41 to 50 of about 100,185 (210)

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Sequence analysis of genes associated with resistance to chloroquine and sulphadoxine pyrimethamine in P. falciparum and P. vivax isolates from the Bannu district of Pakistan

Brazilian Journal of Infectious Diseases, 2013
Plasmodium vivax and Plasmodium falciparum are becoming resistant to drugs including antifolates, sulphonamides and chloroquine. This study was focused at sequence analysis of resistant genes of these parasites against sulphadoxine–pyrimethamine and ...
Lubna Khatoon, Frederick N. Baliraine, Salman A. Malik, Guiyun Yan   +3 more
doaj   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. [PDF]

PLoS ONE, 2011
Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium
María B Cassera, Keith Z Hazleton, Emilio F Merino, Nicanor Obaldia, Meng-Chiao Ho, Andrew S Murkin, Richard DePinto, Jemy A Gutierrez, Steven C Almo, Gary B Evans, Yarlagadda S Babu, Vern L Schramm   +11 more
doaj   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso

Malaria Journal, 2013
Background Malaria can be caused by five Plasmodium species. Due to their higher prevalence, much of the research concentrates on Plasmodium falciparum and Plasmodium vivax. In Burkina Faso, where P.
Gnémé Awa, Guelbéogo Wamdaogo M, Riehle Michelle M, Tiono Alfred B, Diarra Amidou, Kabré Gustave B, Sagnon N’falé, Vernick Kenneth D   +7 more
doaj   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, EarlyView.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

KLASIFIKASI PERKEMBANGBIAKAN PLASMODIUM PENYEBAB PENYAKIT MALARIA DALAM SEL DARAH MERAH MANUSIA DENGAN MENGGUNAKAN SUPPORT VECTOR MACHINE (SVM) DI KOTA JAYAPURA-PAPUA

Ilkom Jurnal Ilmiah, 2018
Malaria adalah penyakit yang ditularkan oleh nyamuk dari manusia dan hewan lain yang disebabkan oleh protozoa parasite (sekelompok mikroorganisme bersel tunggal) dalam tipe Plasmodium.
Abd. Rachman Dayat, Nur Ain Banyal
doaj   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, EarlyView.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

Comparative Evaluation of Available Immune-Chromatographic Tests Used for Detection of Plasmodium Species, A Tertiary Care Hospital Experience

Pakistan Armed Forces Medical Journal
Objective: To test the sensitivity of locally available strips for the detection of Plasmodium Vivax and Plasmodium Falciparum species at a tertiary care hospital. Study Design: Cross-sectional study.
Nabila Rafique, Mohammad Abdul Naeem, Maria Khan, Muhammad Bilal Asghar, Zohra Farooq, Sobia Umar   +5 more
doaj   +1 more source