Results 41 to 50 of about 301,675 (354)

Simple Molecular Methods for Early Detection of Chloroquine Drug Resistance in Plasmodium vivax and Plasmodium falciparum [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Malaria is a human disease of which causes high morbidity and mortality. In Plasmodium falciparum malaria, the resistance to antimalarial drugs, especially chloroquine (CQ) is one of the paramount factors contributing to the global ...
Gurjeet Singh, Raksha Singh, Anant Dattatraya Urhehar   +2 more
doaj   +1 more source

The role of Plasmodium falciparum var genes in malaria in pregnancy [PDF]

, 2004
Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected ...
Andrews, Baruch, Beeson, Beeson, Beeson, Brabin, Buffet, Chen, Costa, Creasey, Dorman, Duffy, Duffy, Flick, Freitas-Junior, Fried, Fried, Fried, Fried, Gardner, Jensen, Kyes, Kyes, Lekana Douki, McCormick, McGregor, Menendez, Menendez, Nosten, O'Neil-Dunne, Reeder, Reeder, Ricke, Rowe, Rowe, Salanti, Salanti, Shulman, Smith, Smith, Smith, Smith, Staalsoe, Staalsoe, Steketee, Su, Suguitan, Taylor, Taylor, Walter, Ward, Winter   +51 more
core   +1 more source

DNA recovery from used malaria RDT to detect Plasmodium species and to assess Plasmodium falciparum genetic diversity: a pilot study in Madagascar

Malaria Journal, 2022
Background Rapid diagnostic tests (RDT) are widely used for malaria diagnosis in Madagascar, where Plasmodium falciparum is the predominant species. Molecular diagnosis is essential for malaria surveillance, but requires additional blood samples for DNA ...
Voahangy Hanitriniaina I. Andrianaranjaka, Elisabeth Ravaoarisoa, Tovonahary A. Rakotomanga, Fanomezantsoa Ralinoro, Danielle A. Doll Rakoto, Ranjàna H. Randrianarivo, Victor Jeannoda, Arsène Ratsimbasoa   +7 more
doaj   +1 more source

Plasmodium falciparum biosynthesizes sulfoglycosphingolipids

Molecular and Biochemical Parasitology, 2007
Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to be involved in the regulation of cell proliferation, differentiation and other developmental cellular events.
Landoni, Malena, Duschak, Vilma Gladys, Peres, Valnice J., Nonami, Hiroshi, Erra Balsells, Rosa, Katzin, Alejandro M., Couto, Alicia Susana   +6 more
openaire   +3 more sources

Protein Sorting in Plasmodium Falciparum [PDF]

Life, 2021
Plasmodium falciparum is a unicellular eukaryote with a very polarized secretory system composed of micronemes rhoptries and dense granules that are required for host cell invasion. P. falciparum, like its relative T. gondii, uses the endolysosomal system to produce the secretory organelles and to ingest host cell proteins.
openaire   +3 more sources

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

Nature, 2019
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective ...
Jonathan Kim, Yong Zi Tan, Kathryn J. Wicht, S. Erramilli, S. K. Dhingra, John Okombo, Jérémie Vendôme, Laura M. Hagenah, Sabrina Giacometti, Audrey L. Warren, K. Nosol, P. Roepe, C. Potter, B. Carragher, A. Kossiakoff, M. Quick, D. Fidock, F. Mancia   +17 more
semanticscholar   +1 more source

Plasmodium falciparum Containment Strategy [PDF]

Medical Journal Armed Forces India, 2008
World Health Organization (WHO) estimates 1.7-2.5 million deaths and 300-500 million cases of malaria each year globally. As an initiative WHO has announced Roll Back Malaria (RBM) programme aimed at 50% reduction in deaths due to malaria by 2010. The RBM strategy recommends combination approach with prevention, care, creating sustainable demand for ...
openaire   +2 more sources

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Science, 2019
Ebb and flow of parasite populations The population genetics of the malaria parasite Plasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power
A. Amambua-Ngwa, L. Amenga-Etego, E. Kamau, R. Amato, A. Ghansah, L. Golassa, M. Randrianarivelojosia, D. Ishengoma, T. Apinjoh, O. Maïga-Ascofaré, B. Andagalu, W. Yavo, M. Bouyou-Akotet, O. Kolapo, Karim Mane, A. Worwui, D. Jeffries, Vikki Simpson, U. d’Alessandro, D. Kwiatkowski, A. Djimde   +20 more
semanticscholar   +1 more source

Comparative transcriptomic analysis of the malaria parasites Plasmodium falciparum and Plasmodium vivax sensitive and resistant strains

Разработка и регистрация лекарственных средств, 2022
Introduction. Malaria is the sixth leading cause of death worldwide. According to a WHO survey (2019-2020), the total number of malaria deaths is estimated to be 409000. Plasmodium falciparum and Plasmodium vivax are major malaria parasites, particularly
S. Sakpal, S. Z. Abdeen, Sh. L. Kothari, V. Bastikar   +3 more
doaj   +1 more source