Results 41 to 50 of about 287,184 (330)

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Barnadas, Céline, Davis, Timothy M., Iga, Jonah, Javati, Sarah, Karunajeewa, Harin, Kiniboro, Benson, Koepfli, Cristian, Malau, Elisheba, Mueller, Ivo, Rare, Lawrence, Reeder, John C., Robinson, Leanne J., Senn, Nicolas, Siba, Peter M., Timinao, Lincoln, Zimmerman, Peter A.   +15 more
core   +3 more sources

A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. [PDF]

PLoS ONE, 2008
Plasmodium falciparum (P. falciparum) secretes hundreds of proteins--including major virulence proteins--into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins contain an N terminal host-targeting (HT) motif composed
Julia J MacKenzie, Noé D Gómez, Souvik Bhattacharjee, Shaina Mann, Kasturi Haldar   +4 more
doaj   +1 more source

Spread of artemisinin resistance in Plasmodium falciparum malaria.

New England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
E. Ashley, M. Dhorda, R. Fairhurst, C. Amaratunga, P. Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Sivanna Mao, Baramey Sam, Chantha Sopha, Char Meng Chuor, C. Nguon, S. Sovannaroth, S. Pukrittayakamee, P. Jittamala, K. Chotivanich, K. Chutasmit, C. Suchatsoonthorn, R. Runcharoen, T. Hien, Nguyen T Thuy-Nhien, N. V. Thanh, N. Phu, Y. Htut, K. Han, K. H. Aye, O. Mokuolu, Rasaq R Olaosebikan, O. Folaranmi, M. Mayxay, Maniphone Khanthavong, B. Hongvanthong, P. Newton, M. Onyamboko, C. Fanello, A. Tshefu, N. Mishra, N. Valecha, A. Phyo, F. Nosten, P. Yi, R. Tripura, S. Borrmann, M. Bashraheil, J. Peshu, M. A. Faiz, A. Ghose, M. Hossain, Rasheda Samad, M. R. Rahman, M. Hasan, Akhterul Islam, Olivo Miotto, R. Amato, B. MacInnis, J. Stalker, D. Kwiatkowski, Zbynek Bozdech, Atthanee Jeeyapant, P. Cheah, Tharisara Sakulthaew, Jeremy Chalk, B. Intharabut, K. Silamut, Sue J Lee, Benchawan Vihokhern, Chanon Kunasol, M. Imwong, J. Tarning, W. J. Taylor, S. Yeung, C. Woodrow, J. Flegg, D. Das, Jeffery L. Smith, M. Venkatesan, C. Plowe, K. Stepniewska, P. Guérin, A. Dondorp, N. Day, N. White   +82 more
semanticscholar   +1 more source

Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]

, 2019
Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate, Le Roch, Karine G, Lu, Yang Y, Noble, William Stafford, Read, David F   +4 more
core   +2 more sources

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda

Allergy, Asthma & Clinical Immunology, 2018
Background Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular ...
Richard Bwanika, Charles D. Kato, Johnson Welishe, Daniel C. Mwandah   +3 more
doaj   +1 more source

Computational identification of signalling pathways in Plasmodium falciparum [PDF]

, 2011
Malaria is one of the world’s most common and serious diseases causing death of about 3 million people each year. Its most severe occurrence is caused by the protozoan Plasmodium falciparum.
Adebiyi, E. F., Brors, B., Eils, R., Isewon, Itunuoluwa, Oyelade, O. J.   +4 more
core   +2 more sources

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +2 more sources

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Molecular identification of Plasmodium species in symptomatic children of Democratic Republic of Congo

Malaria Journal, 2018
Background Worldwide, the highest malaria mortality is due to Plasmodium falciparum infection. However, other species of Plasmodium (Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi) can also cause malaria.
Hugo Kavunga-Membo, Gillon Ilombe, Justin Masumu, Junior Matangila, Joël Imponge, Emile Manzambi, Francis Wastenga, Dieudonné Mumba Ngoyi, Jean-Pierre Van Geetruyden, Jean Jacques Muyembe   +9 more
doaj   +1 more source

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

Nature, 2019
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective ...
Jonathan Kim, Yong Zi Tan, Kathryn J. Wicht, S. Erramilli, Satish K. Dhingra, John Okombo, Jérémie Vendôme, Laura M. Hagenah, Sabrina Giacometti, Audrey L. Warren, K. Nosol, P. Roepe, C. Potter, B. Carragher, A. Kossiakoff, M. Quick, D. Fidock, F. Mancia   +17 more
semanticscholar   +1 more source