Results 41 to 50 of about 302,576 (367)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission-blocking target. [PDF]

FEBS Lett
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Huppertz F, Caturelli MS, Lehmann LS, Kurth F, Maier AG, Matuschewski K.   +5 more
europepmc   +2 more sources

Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift [PDF]

, 2014
<b>Background</b> Understanding of malaria pathogenesis caused by Plasmodium falciparum has been greatly deepened since the introduction of in vitro culture system, but the lack of a method to enrich ring-stage parasites remains a technical ...
Chan, Sherwin, Franke, Thomas, Geislinger, Thomas M, Moll, Kirsten, Wahlgren, Mats, Wixforth, Achim   +5 more
core   +1 more source

A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. [PDF]

PLoS ONE, 2008
Plasmodium falciparum (P. falciparum) secretes hundreds of proteins--including major virulence proteins--into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins contain an N terminal host-targeting (HT) motif composed
Julia J MacKenzie, Noé D Gómez, Souvik Bhattacharjee, Shaina Mann, Kasturi Haldar   +4 more
doaj   +1 more source

Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]

, 2019
Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate, Le Roch, Karine G, Lu, Yang Y, Noble, William Stafford, Read, David F   +4 more
core   +2 more sources

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V, Kelly, John M, Meyer, David J, Miles, Michael A, Taylor, Martin C, Wilkinson, Shane R   +5 more
core   +4 more sources

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda

Allergy, Asthma & Clinical Immunology, 2018
Background Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular ...
Richard Bwanika, Charles D. Kato, Johnson Welishe, Daniel C. Mwandah   +3 more
doaj   +1 more source

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]

, 2011
Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Bourdoncle, P., Chandran, S., Dandavate, V., Langsley, G., Meissner, M., Ndjembo-Ezougou, C., Rached, F.B., Talabani, H., Tatu, U., Yera, H.   +9 more
core   +1 more source

Cessation of mass drug administration for lymphatic filariasis in Zanzibar in 2006: was transmission interrupted? [PDF]

, 2015
BACKGROUND: Lymphatic filariasis (LF) is targeted for elimination through annual mass drug administration (MDA) for 4-6 years. In 2006, Zanzibar stopped MDA against LF after five rounds of MDA revealed no microfilaraemic individuals during surveys at ...
Cullen, Katelyn J, Desai, Monica, Harris, Ross J, Hope, Vivian D, Ijaz, Samreen, Mandal, Sema, Ncube, Fortune, Parry, John V, Platt, Lucy, Shute, Justin, Vickerman, Peter   +10 more
core   +11 more sources

Experience and Challenges from Clinical Trials with Malaria Vaccines in Africa. [PDF]

, 2013
Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades ...
A Nyika, A Olotu, A Roca-Feltrer, AA Holder, AJ Luty, AVS Hill, B Moonen, Bernhards Ogutu, Beverly Msambichaka, BF Chumpitazi, Bouharoun-Tayoun H Druilhe P, C Guinovart, C Roussilhon, C Swysen, DA Chokshi, DA Diallo, E Peduzzi, Eakin, Bull SS, Riley K,Reeves MM, Gutierrez S, McLaughlin P, FM Ndungu, FM Ndungu, FM Thompson, Grace Mwangoka, H Bouharoun-Tayoun, HL Smits, I Nebie, J Schantz-Dunn, JL Sarthou, K Miura, K Shubis, KE Kester, KE Kester, KP Asante, L Schwartz, M Roestenberg, M Roestenberg, Marcel Tanner, Maxmillian Mpina, MP Girad, Nahya Salim, NC Iriemenam, NJ White, OK Doumbo, PG Cech, PL Alonso, PL Alonso, PL Alonso, PO Tindana, R Chilengi, RR Taylor, S Casares, Salim Abdulla, Seif Shekalaghe, Shubis Kafuruki, SJ Rogerson, SL Hoffman, ST Agnandji, ST Agnandji, T Smith, T Smith, T Smith, TA Lang, The malERA Consultative Group on Vaccines, Tutu Mzee, V Gardette, V Moorthy, WHO, WHO, YP Shi   +67 more
core   +3 more sources