Results 51 to 60 of about 302,576 (367)

Molecular identification of Plasmodium species in symptomatic children of Democratic Republic of Congo

Malaria Journal, 2018
Background Worldwide, the highest malaria mortality is due to Plasmodium falciparum infection. However, other species of Plasmodium (Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi) can also cause malaria.
Hugo Kavunga-Membo, Gillon Ilombe, Justin Masumu, Junior Matangila, Joël Imponge, Emile Manzambi, Francis Wastenga, Dieudonné Mumba Ngoyi, Jean-Pierre Van Geetruyden, Jean Jacques Muyembe   +9 more
doaj   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi. [PDF]

ChemMedChem
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Franco CA, Varejão JOS, Ceravolo IP, Machado VM, Krettli AU, de Melo Resende D, Murta SMF, Martins FT, Pilau EJ, Montes VR, Kohlhoff M, Varejão EVV.   +11 more
europepmc   +2 more sources

Sri Lanka Malaria Maps [PDF]

, 2003
BACKGROUND: Despite a relatively good national case reporting system in Sri Lanka, detailed maps of malaria distribution have not been publicly available.
Amerasinghe, Felix P, Briët, Olivier JT, Gunawardena, Dissanayake M, van der Hoek, Wim   +3 more
core   +3 more sources

Plasmodium falciparum infection and the risk of anemia in school children [PDF]

Universa Medicina, 2013
Background According to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum ...
Suriyani Tan, Taniawati Supali, Heri Wibowo   +2 more
doaj  

Accuracy of malaria diagnosis by clinical laboratories in Belgium

Malaria Journal, 2019
Background The Belgian Reference Laboratory for Plasmodium offers a free-of-charge reference testing of malaria-positive or doubtful samples to clinical laboratories.
Laura Loomans, Anali Conesa Botella, Agnes D’hondt, Jacob Verschueren, Dorien Van den Bossche, Marjan Van Esbroeck, Jan Jacobs   +6 more
doaj   +1 more source

Simple Molecular Methods for Early Detection of Chloroquine Drug Resistance in Plasmodium vivax and Plasmodium falciparum [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Malaria is a human disease of which causes high morbidity and mortality. In Plasmodium falciparum malaria, the resistance to antimalarial drugs, especially chloroquine (CQ) is one of the paramount factors contributing to the global ...
Gurjeet Singh, Raksha Singh, Anant Dattatraya Urhehar   +2 more
doaj   +1 more source

Evaluation of FRET real-time PCR assay for rapid detection and differentiation of Plasmodium species in returning travellers and migrants

Malaria Journal, 2008
Background A simple real-time PCR assay using one set of primer and probe for rapid, sensitive and quantitative detection of Plasmodium species, with simultaneous differentiation of Plasmodium falciparum from the three other Plasmodium species ...
Pistone Thierry, Receveur Marie-Catherine, Fregeville Frédéric, Melinard Laurence, Boucher Sébastien, Millet Pascal, Safeukui Innocent, Fialon Pierre, Vincendeau Philippe, Fleury Hervé, Malvy Denis   +10 more
doaj   +1 more source

DNA recovery from used malaria RDT to detect Plasmodium species and to assess Plasmodium falciparum genetic diversity: a pilot study in Madagascar

Malaria Journal, 2022
Background Rapid diagnostic tests (RDT) are widely used for malaria diagnosis in Madagascar, where Plasmodium falciparum is the predominant species. Molecular diagnosis is essential for malaria surveillance, but requires additional blood samples for DNA ...
Voahangy Hanitriniaina I. Andrianaranjaka, Elisabeth Ravaoarisoa, Tovonahary A. Rakotomanga, Fanomezantsoa Ralinoro, Danielle A. Doll Rakoto, Ranjàna H. Randrianarivo, Victor Jeannoda, Arsène Ratsimbasoa   +7 more
doaj   +1 more source

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources