Results 51 to 60 of about 296,027 (331)

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Evaluation of FRET real-time PCR assay for rapid detection and differentiation of Plasmodium species in returning travellers and migrants

Malaria Journal, 2008
Background A simple real-time PCR assay using one set of primer and probe for rapid, sensitive and quantitative detection of Plasmodium species, with simultaneous differentiation of Plasmodium falciparum from the three other Plasmodium species ...
Pistone Thierry, Receveur Marie-Catherine, Fregeville Frédéric, Melinard Laurence, Boucher Sébastien, Millet Pascal, Safeukui Innocent, Fialon Pierre, Vincendeau Philippe, Fleury Hervé, Malvy Denis   +10 more
doaj   +1 more source

Comparative transcriptomic analysis of the malaria parasites Plasmodium falciparum and Plasmodium vivax sensitive and resistant strains

Разработка и регистрация лекарственных средств, 2022
Introduction. Malaria is the sixth leading cause of death worldwide. According to a WHO survey (2019-2020), the total number of malaria deaths is estimated to be 409000. Plasmodium falciparum and Plasmodium vivax are major malaria parasites, particularly
S. Sakpal, S. Z. Abdeen, Sh. L. Kothari, V. Bastikar   +3 more
doaj   +1 more source

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Nature Communications, 2018
The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the Plasmodium falciparum ...
Leila S Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, B. Witkowski, R. Fairhurst, F. Ariey, D. Ménard, D. Fidock   +11 more
semanticscholar   +1 more source

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

Immunological Reviews, 2019
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja T. R. Jensen, Y. Adams, L. Hviid
semanticscholar   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources

Gametocytogenesis: the puberty of Plasmodium falciparum.

Malaria journal, 2004
The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P.
Arthur M. Talman, Arthur M. Talman, F. Ellis McKenzie, Frédéric Ariey, Olivier Domarle, Vincent Robert, Vincent Robert   +6 more
openaire   +4 more sources

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

Perfil clínico y parasitológico de la malaria por Plasmodium falciparum y Plasmodium vivax no complicada en Córdoba, Colombia.

Revista de la Facultad de Medicina, 2015
Antecedentes. En Colombia existen pocos estudios que buscan encontrar diferencias clínicas y parasitológicas en la malaria causada por Plasmodium falciparum y Plasmodium vivax.  Objetivo.
Angélica Knudson Ospina, Ricardo Sánchez Pedraza, Manuel Alberto Pérez Mazorra, Liliana Jazmín Cortés Cortés, Ángela Patricia Guerra Vega, Rubén Santiago Nicholls Orejuela   +5 more
doaj   +1 more source

Human Infections with Plasmodium knowlesi, the Philippines. [PDF]

, 2008
Five human cases of infection with the simian malaria parasite Plasmodium knowlesi from Palawan, the Philippines, were confirmed by nested PCR. This study suggests that this zoonotic infection is found across a relatively wide area in Palawan and ...
Bell, David, Chiodini, Peter, Curameng, Peter, Espina, Ronald, Espino, Fe, Lee, Kim-Sung, Luchavez, Jennifer, Nolder, Debbie, Singh, Balbir, Sutherland, Colin   +9 more
core   +3 more sources