Results 111 to 120 of about 530,210 (299)
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang+17 more
wiley +1 more source
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I.+7 more
core +4 more sources
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida+8 more
wiley +1 more source
Plasmodium parasites have a complex life cycle that transitions between mosquito and mammalian hosts, and undergo continuous cellular remodeling to adapt to various drastic environments.
Akancha Mishra+4 more
doaj +1 more source
A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery+13 more
doaj +1 more source
Survivorship Of Anopheles gambiae In Relation To Malaria Transmission In Ilorin, Nigeria [PDF]
For the first time in Africa, an entomological study went beyond the conventional practice of determining parity and survival rates of field-collected adult anopheline mosquitoes but also related these variables to duration of Plasmodium sporogony and ...
Ande, Adeolu Taiwo+1 more
core +1 more source
Detecting signatures of balancing selection to identify targets of anti-parasite immunity.
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core +1 more source
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas+10 more
wiley +1 more source
Half of the world’s population lives at risk for malaria. The intraerythrocytic life cycle of Plasmodium spp. is responsible for clinical manifestations of malaria; therefore, knowledge of the parasite’s ability to survive within the erythrocyte is ...
David W. Cobb+5 more
semanticscholar +1 more source
Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences [PDF]
There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes.
Tripet, F
core +1 more source