Results 111 to 120 of about 530,210 (299)

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

open access: yesAdvanced Science, EarlyView.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang   +17 more
wiley   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

open access: yes, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I.   +7 more
core   +4 more sources

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

open access: yesChemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida   +8 more
wiley   +1 more source

Autophagy protein Atg7 is essential for maintaining malaria parasite cellular homeostasis and organelle biogenesis

open access: yesmBio
Plasmodium parasites have a complex life cycle that transitions between mosquito and mammalian hosts, and undergo continuous cellular remodeling to adapt to various drastic environments.
Akancha Mishra   +4 more
doaj   +1 more source

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

open access: yesPLoS Pathogens, 2012
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery   +13 more
doaj   +1 more source

Survivorship Of Anopheles gambiae In Relation To Malaria Transmission In Ilorin, Nigeria [PDF]

open access: yes, 2008
For the first time in Africa, an entomological study went beyond the conventional practice of determining parity and survival rates of field-collected adult anopheline mosquitoes but also related these variables to duration of Plasmodium sporogony and ...
Ande, Adeolu Taiwo   +1 more
core   +1 more source

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

open access: yes, 2010
Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas   +10 more
wiley   +1 more source

The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle

open access: yesMsphere, 2017
Half of the world’s population lives at risk for malaria. The intraerythrocytic life cycle of Plasmodium spp. is responsible for clinical manifestations of malaria; therefore, knowledge of the parasite’s ability to survive within the erythrocyte is ...
David W. Cobb   +5 more
semanticscholar   +1 more source

Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences [PDF]

open access: yes, 2009
There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes.
Tripet, F
core   +1 more source

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