Results 121 to 130 of about 515,233 (262)

In Vitro Activity of wALADin Benzimidazoles against Different Life Cycle Stages of Plasmodium Parasites [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations ...
Lentz, C., Sattler, J., Fendler, M., Gottwalt, S., Halls, V., Strassel, S., Arriens, S., Hannam, J., Specht, S., Famulok, M., Mueller, A., Hoerauf, A., Pfarr, K.   +12 more
openaire   +4 more sources

Subtle stressors—Strong responses. Consistent negative effects of avian blood parasites on phenotypic and demographic traits across songbirds

Journal of Animal Ecology, EarlyView.
Avian blood parasites are widespread and often considered benign, yet mounting evidence suggests they subtly impair host traits. This meta‐analysis is timely and necessary to quantify their true impact across systems, challenging assumptions and highlighting overlooked consequences for fitness and population dynamics. Abstract Stressors that subtly yet
Marius Grabow, Sirkka Mang, Niels Blaum, Ralph Tiedemann, Viktoriia Radchuk, Stephanie Kramer‐Schadt   +5 more
wiley   +1 more source

Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]

, 2006
The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Survivorship Of Anopheles gambiae In Relation To Malaria Transmission In Ilorin, Nigeria [PDF]

, 2008
For the first time in Africa, an entomological study went beyond the conventional practice of determining parity and survival rates of field-collected adult anopheline mosquitoes but also related these variables to duration of Plasmodium sporogony and ...
Ande, Adeolu Taiwo, Olayemi, Israel Kayode   +1 more
core   +1 more source

Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite

Nature Communications, 2016
The functions of many putative membrane transport proteins of malaria parasites are unknown. Here, Kenthirapalan et al. use mutant strains carrying targeted gene deletions to study the functions of 35 such proteins during the life cycle of Plasmodium ...
Sanketha Kenthirapalan, Andrew P. Waters, Kai Matuschewski, Taco W. A. Kooij   +3 more
doaj   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Polychromophilus spp. (Haemosporida: Plasmodiidae): First Molecular Detection in Bat Flies From Brazilian Bats

Integrative Zoology, EarlyView.
This study identifies Polychromophilus sp. in blood‐feeding flies (Basilia speiseri and Basilia lindolphoi) from Myotis nigricans bats in Brazil, marking the first molecular detection of the parasite in an insect vector in this country. Two haplotypes were identified, both within the Polychromophilus murinus group.
Bruno S. Mathias, Vinicio R. De Lima, Gustavo Graciolli, Nubia R. M. F. Rocha, Jaciara O. J. Costa, Herbert S. Soares, Arlei Marcili, Karin Kirchgatter   +7 more
wiley   +1 more source

Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections [PDF]

, 2007
We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi ...
Abdel-Wahab, Alano, Babiker, Bell, Cheeseman, Damien R. Drew, De Roode, De Roode, De Roode, Dye, Ferguson, Ferguson, Foster, Gardner, Gautret, Hamilton, Khan, Mackinnon, Nee, Paterson, Paul, Paul, Paul, Pinheiro, Ranford-Cartwright, Read, Read, Read, Reece, Reece, Reece, Sarah E. Reece, Schall, Schall, Schneider, Shutler, Sinden, Taylor, Taylor, Wargo, Wargo, West, West, West, West   +44 more
core   +1 more source