Results 51 to 60 of about 530,210 (299)
Nature Communications, 2023 Within-host survival and between-host transmission are key life-history traits of single-celled malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to predict malaria epidemiology, drug resistance, and virulence ...
Paola Carrillo-Bustamante +3 more
doaj +1 more source
Science Translational Medicine, 2022 Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and in vivo ...
Lauren B. Arendse +29 more
semanticscholar +1 more source
Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]
, 2017 Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani +5 more
core +1 more source
The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]
, 2012 <b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier +27 more
core +5 more sources
Motile mosquito stage malaria parasites: ready for their close‐up
EMBO Molecular Medicine, 2021 Many stages of the complex Plasmodium parasite life cycle, the eukaryotic pathogen that causes malaria, are extracellular and motile. This motility is essential for life cycle progression, and two studies in this issue of EMBO Molecular Medicine (Hopp et
Ashley Vaughan
doaj +1 more source
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]
, 2015 BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M +5 more
core +2 more sources
PLoS Computational Biology, 2018 Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies.
Alyaa M Abdel-Haleem +7 more
doaj +1 more source
Deep Learning Methods in Predicting Gene Expression Levels for the Malaria Parasite
Frontiers in Genetics, 2021 Malaria is a mosquito-borne disease caused by single-celled blood parasites of the genus Plasmodium. The most severe cases of this disease are caused by the Plasmodium species, Falciparum. Once infected, a human host experiences symptoms of recurrent and
Tuan Tran +2 more
doaj +1 more source
The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]
, 2013 Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M +9 more
core +4 more sources
The effect of backstepping control technique to break-up the life cycle of plasmodium parasite [PDF]
AIP Conference Proceedings, 2019 Nagadevi Bala Nagaram +2 more
openalex +3 more sources