Results 51 to 60 of about 67,974 (216)
Structural Insights Into Key Plasmodium Proteases as Therapeutic Drug Targets
Frontiers in Microbiology, 2019 Malaria, caused by protozoan of genus Plasmodium, remains one of the highest mortality infectious diseases. Malaria parasites have a complex life cycle, easily adapt to their host’s immune system and have evolved with an arsenal of unique proteases which
Manasi Mishra +3 more
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Systems analysis of host-parasite interactions. [PDF]
, 2015 Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema +3 more
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Cells, 2020 The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium.
David S. Guttery +8 more
doaj +1 more source
Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare. [PDF]
, 2018 Currently, there are very few studies of avian malaria that investigate relationships among the host-vector-parasite triad concomitantly. In the current study, we experimentally measured the vector competence of several Culex mosquitoes for a newly ...
Barker, Christopher M +5 more
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The Integral Plasmodium Life Cycle Phenomenon: Gametocyte Genes [PDF]
Journal of Bacteriology & Parasitology, 2015 Gametocytes are the sexual stages of the Plasmodium species. The transmission of parasite relies on these gametocytes which are the crucial link in its life cycle. The biology of parasitic life cycle is complex with the invasion of host red blood cells (RBCs) by merozoites after the pre-erythrocytic invasion and followed with erythrocytic invasions and
openaire +1 more source
The role of cGMP signalling in regulating life cycle progression of Plasmodium [PDF]
Microbes and Infection, 2012 The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and ...
Hopp, Christine S +2 more
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The role of the liver in the migration of parasites of global significance
Parasites & Vectors, 2019 Many parasites migrate through different tissues during their life-cycle, possibly with the aim to enhance their fitness. This is true for species of three parasite genera of global importance, Ascaris, Schistosoma and Plasmodium, which cause significant
Gwendoline Deslyper +3 more
doaj +1 more source
Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP [PDF]
, 2005 Plasmodium falciparum, the causative agent of malaria, relies on a sophisticated protein secretion system for host cell invasion and transformation.
Cowman, Alan F. +6 more
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Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy
Frontiers in Cellular and Infection Microbiology, 2021 Malaria is a parasitic disease that represents a public health problem worldwide. Protozoans of the Plasmodium genus are responsible for causing malaria in humans.
Daffiny Sumam de Oliveira +4 more
doaj +1 more source
The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]
, 2013 Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M +9 more
core +4 more sources