Results 51 to 60 of about 515,233 (262)

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

mBio, 2021
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission.
Sudhir Kumar, Meseret T. Haile, Michael R. Hoopmann, Linh T. Tran, Samantha A. Michaels, Seamus R. Morrone, Kayode K. Ojo, Laura M. Reynolds, Ulrike Kusebauch, Ashley M. Vaughan, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen   +12 more
doaj   +1 more source

Ecology: a prerequisite for malaria elimination and eradication [PDF]

, 2010
* Existing front-line vector control measures, such as insecticide-treated nets and residual sprays, cannot break the transmission cycle of Plasmodium falciparum in the most intensely endemic parts of Africa and the Pacific * The goal of malaria ...
A Bhattarai, A Kiszewski, A Saul, Anna Dornhaus, Arlyne Beeche, AY Vittor, BL Sharp, C Garrett-Jones, C Lengeler, Christian Borgemeister, CR Rodriguez-Saona, D Fish, DL Smith, DL Smith, Durland Fish, EJ Scholte, EO Lyimo, EP Odum, FO Okumu, G Giglioli, G MacDonald, G Müller, G Müller, G Zhou, Gerry F. Killeen, GF Killeen, GF Killeen, GF Killeen, GJ Devine, GJ Yang, GP Garcia, GW Fegan, H Briegel, H Mshinda, H Pates, H Ranson, H Townson, HD Trung, Heather M. Ferguson, HM Ferguson, HM Ferguson, I Bates, I Bates, I Tirados, IN Lyimo, J Cox-Singh, J Keiser, J Keiser, JA Najera, JA Patz, JA Patz, JC Beier, John E. Gimnig, JP Grieco, L Kelly-Hope, L Molineaux, L Roberts, M Coluzzi, M Rowland, MA Riehle, Michael Gottlieb, Mir S. Mulla, MJ Kirby, MN Bayoh, MT Gillies, MT Gillies, MT Gillies, NJ Govella, R Feachem, RL Kouznetsov, SJ Ceesay, TW Scott, U Fillinger, W Gu, W Gu, W Gu, WA Hawley, WP O'Meara, Y Geissbuhler   +78 more
core   +4 more sources

The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

Science Translational Medicine, 2022
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and in vivo ...
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, C. Pasaje, L. Godoy, S. Dey, Liezl Gibhard, S. Ghidelli-Disse, G. Drewes, M. Bantscheff, M. Lafuente-Monasterio, S. Fienberg, Lynn Wambua, Samuel Gachuhi, D. Coertzen, Mariëtte E. van der Watt, J. Reader, A. Aswat, Erica Erlank, N. Venter, Nimisha Mittal, M. Luth, S. Ottilie, E. Winzeler, L. Koekemoer, L. Birkholtz, J. Niles, M. Llinás, D. Fidock, K. Chibale   +29 more
semanticscholar   +1 more source

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites

Nature Communications, 2023
Within-host survival and between-host transmission are key life-history traits of single-celled malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to predict malaria epidemiology, drug resistance, and virulence ...
Paola Carrillo-Bustamante, Giulia Costa, Lena Lampe, Elena A. Levashina   +3 more
doaj   +1 more source

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]

, 2012
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier, AM Talman, Andrew Tomlins, C Aurrecoechea, Christian Doerig, CJ Tonkin, EK De Silva, F Silvestrini, J Miao, JA Braks, KG Le Roch, L O’Regan, L Reininger, L Reininger, L Reininger, LM Quarmby, Luc Reininger, M Dyer, MC Bruce, Miguel Garcia, N Hall, P Alano, R Carter, RE Sinden, S Eksi, S Singh, SM Khan, Sylke Müller   +27 more
core   +5 more sources

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Motile mosquito stage malaria parasites: ready for their close‐up

EMBO Molecular Medicine, 2021
Many stages of the complex Plasmodium parasite life cycle, the eukaryotic pathogen that causes malaria, are extracellular and motile. This motility is essential for life cycle progression, and two studies in this issue of EMBO Molecular Medicine (Hopp et
Ashley Vaughan
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting.

PLoS Computational Biology, 2018
Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies.
Alyaa M Abdel-Haleem, Hooman Hefzi, Katsuhiko Mineta, Xin Gao, Takashi Gojobori, Bernhard O Palsson, Nathan E Lewis, Neema Jamshidi   +7 more
doaj   +1 more source