Results 81 to 90 of about 515,233 (262)
Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi. [PDF]
Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.
Lorena González-López+8 more
doaj +1 more source
Cryptosporidium is a leading infectious cause of diarrhea around the world associated with waterborne outbreaks, community spread, or zoonotic transmission.
Elizabeth D. English+3 more
semanticscholar +1 more source
Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar+15 more
wiley +1 more source
Dendritic cells in plasmodium infection [PDF]
Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso+15 more
core +2 more sources
Apicomplexan parasites of the genera Theileria and Plasmodium have complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host.
Heussler V.T., Stanway R.R.
doaj +1 more source
Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy
Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5′-monophosphate–mimicking nucleoside sulfamates.
S. Xie+36 more
semanticscholar +1 more source
In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments
Here, an open microfluidic platform termed “µ‐Blood” is reported for real‐time, continuous monitoring of Babesia microti infection dynamics in vitro. µ‐Blood allows direct interrogation of whole blood with preserved integrity of the original whole blood microenvironment through an extended period (e.g., 72 h with mouse red blood cells) ex vivo. µ‐Blood
Chao Li+4 more
wiley +1 more source
A single-cell atlas of Plasmodium falciparum transmission through the mosquito
Here the authors use single-cell RNA-seq to profile the transmission stages of the human malaria parasite Plasmodium falciparum as it progresses through the Anopheles mosquito.
Eliana Real+11 more
doaj +1 more source
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida+8 more
wiley +1 more source
Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members. [PDF]
Emerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population. P.
A Berry+61 more
core +3 more sources