Results 81 to 90 of about 530,210 (299)

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi. [PDF]

PLoS ONE, 2017
Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.
Lorena González-López, Rebeca Carballar-Lejarazú, Gerardo Arrevillaga Boni, Leticia Cortés-Martínez, Febe Elena Cázares-Raga, Abel Trujillo-Ocampo, Mario H Rodríguez, Anthony A James, Fidel de la Cruz Hernández-Hernández   +8 more
doaj   +1 more source

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

Detecting Dengue in Flight: Leveraging Machine Learning to Analyze Mosquito Flight Patterns for Infection Detection

Advanced Biology, EarlyView.
Dengue infection alters mosquito flight behavior, enabling detection using machine learning classifiers. This study analyzes 3D flight trajectories and evaluates multiple models, showing that longer sequence lengths improve classification performance.
Nouman Javed, Adam J. López‐Denman, Prasad N. Paradkar, Asim Bhatti   +3 more
wiley   +1 more source

Cellular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells

Parasite, 2008
Apicomplexan parasites of the genera Theileria and Plasmodium have complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host.
Heussler V.T., Stanway R.R.
doaj   +1 more source

Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites: Plasmodium and Babesia

Frontiers in Cellular and Infection Microbiology, 2021
Malaria caused by Plasmodium species and transmitted by Anopheles mosquitoes affects large human populations, while Ixodes ticks transmit Babesia species and cause babesiosis.
Vitomir Djokic, Sandra C. Rocha, Nikhat Parveen   +2 more
doaj   +1 more source

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

Science, 2022
Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5′-monophosphate–mimicking nucleoside sulfamates.
S. Xie, R. Metcalfe, Elyse Dunn, C. Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, S. Wittlin, S. Nie, M. Luth, Liting Ma, Mi-Sook Kim, C. Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, F. Houghton, Alisje Churchyard, M. T. Famodimu, Daniel C. Barry, D. Gillett, S. Dey, Clara C. Kosasih, W. Newman, J. Niles, Marcus C. S. Lee, J. Baum, S. Ottilie, E. Winzeler, D. Creek, N. Williamson, M. Parker, S. Brand, S. Langston, L. Dick, M. Griffin, A. Gould, Leann Tilley   +36 more
semanticscholar   +1 more source

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern [PDF]

, 2003
The var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors.
Sue A. Kyes, Zoe Christodoulou, Ahmed Raza, Paul Horrocks, Robert Pinches, J. Alexandra Rowe, Chris I. Newbold, Aguiar, Baruch, Beeson, Berendt, Bonnefoy, Brabin, Buffet, Bull, Chen, Chen, Church, Duffy, Fidock, Fowler, Freitas-Junior, Fried, Fried, Fried, Gardner, Gardner, Goda, Kyes, Kyes, Lambros, Lekana Douki, Marsh, Newbold, Pouvelle, Reeder, Ricke, Roberts, Robson, Rowe, Rowe, Rubio, Salanti, Scherf, Smith, Smith, Smith, Su, Taylor, Trager, Vazquez-Macias, Voss   +51 more
core   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

A single-cell atlas of Plasmodium falciparum transmission through the mosquito

Nature Communications, 2021
Here the authors use single-cell RNA-seq to profile the transmission stages of the human malaria parasite Plasmodium falciparum as it progresses through the Anopheles mosquito.
Eliana Real, Virginia M. Howick, Farah A. Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S. Davidson, Sunil Kumar Dogga, Adam J. Reid, Jake Baum, Mara K. N. Lawniczak   +11 more
doaj   +1 more source