Results 51 to 60 of about 470,234 (268)

Neurochemical changes in basal ganglia affect time perception in parkinsonians

Journal of Biomedical Science, 2018
Background Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision making and time perception.
Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini, Silmar Teixeira   +13 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Combining genotypic and phenotypic analyses on single mutant zebrafish larvae

MethodsX, 2018
Zebrafish is a powerful animal model used to study vertebrate embryogenesis, organ development and diseases (Gut et al., 2017) [1]. The usefulness of the model was established as a result of various large forward genetic screens identifying mutants in ...
Barbara Dupret, Pamela Völkel, Pauline Follet, Xuefen Le Bourhis, Pierre-Olivier Angrand   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

Alzheimer’s Research & Therapy, 2018
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact.
Sylvie L. Lesuis, Lianne Hoeijmakers, Aniko Korosi, Susanne R. de Rooij, Dick F. Swaab, Helmut W. Kessels, Paul J. Lucassen, Harm J. Krugers   +7 more
doaj   +1 more source

Rehabilitation and Plasticity [PDF]

, 2013
Therapies for effective neurorehabiltiation are in part based on brain mechanism commonly described as neuroplasticity. These therapeutic approaches emphasize the re-learning of functionality that was lost due to the injury through reorganization of neural circuits in the remaining intact tissue.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke

Scientific Reports
In healthy adults different language abilities—sentence processing versus emotional prosody—are supported by the left (LH) versus the right hemisphere (RH), respectively.
Kelly C. Martin, Anna Seydell-Greenwald, Peter E. Turkeltaub, Catherine E. Chambers, William D. Gaillard, Elissa L. Newport   +5 more
doaj   +1 more source

A simplified microwave-based motion detector for home cage activity monitoring in mice

Journal of Biological Engineering, 2017
Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping.
Andreas Genewsky, Daniel E. Heinz, Paul M. Kaplick, Kasyoka Kilonzo, Carsten T. Wotjak   +4 more
doaj   +1 more source