Results 61 to 70 of about 118,485 (254)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Phenotypic Plasticity Index as a Strategy for Selecting Water-Stress-Adapted Coffee Genotypes. [PDF]

Plants (Basel), 2023
Dos Santos CS, de Freitas AF, da Silva GHB, Pennacchi JP, Figueiredo de Carvalho MA, Santos MO, Junqueira de Moraes TS, de Rezende Abrahão JC, Pereira AA, Carvalho GR, Botelho CE, Silva VA.   +11 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Road Pavement Thickness and Construction Depth Optimization Using Treated and Untreated Artificially-Synthesized Expansive Road Subgrade Materials with Varying Plasticity Index. [PDF]

Materials (Basel), 2022
Amakye SYO, Abbey SJ, Booth CA, Oti J.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Plasticidade morfoanatômica foliar de Tibouchina clavata (Melastomataceae) ocorrente em duas formações de restinga

Rodriguésia
Resumo Respostas plásticas em plantas podem ser induzidas pela heterogeneidade espacial, sendo a restinga um ecossistema favorável á compreensão dessas respostas em função das condições ambientais limitantes que apresenta.
Maick Willian Amorim, João Carlos Ferreira de Melo Júnior   +1 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

EFFECT OF USING PETROLEUM PRODUCTS ON THE CHARACTERISTICS OF EXPANSIVE SOIL

Journal of Engineering and Sustainable Development, 2017
Expansive soil is the soil whose volume changes according to the changing of moisture content included in it. When the soil absorbs water this will lead to an increase in its volume and vice-versa. The swelling of soil leads to structural damage such as
Adel H. Majeed, Muhannd W. Majeed
doaj  

The Effect of Soft Nanoparticle Size and Concentration on Wear Behavior in Mixed Lubrication Conditions

Tribology Online
This research study investigates how incorporating soft nanoparticles affect the wear behavior and the characteristics of the materials in three-body mixed lubrication conditions.
Yunn-Lin Hwang, Adhitya, Jeng-Haur Horng
doaj   +1 more source