Results 81 to 90 of about 3,860,038 (286)

Comparative study on complications of screws versus plates for comminuted radial head and neck fractures with two or three fragments

open access: yesFrontiers in Surgery
BackgroundThis retrospective study aimed to compare the efficacy of internal fixation using headless compression screws (HCS) and radial head locking plate (RLP) for comminuted radial head and neck fractures with no more than 3 displaced fragments ...
Yuliang Fu   +11 more
doaj   +1 more source

The Case Examination of Detection of Structural Damages on a Plate using Wavelet Transform [PDF]

open access: yesInternational Journal of Advanced Design and Manufacturing Technology, 2020
Sometimes, suddenly or gradually structural or nonstructural damages are created in structure’s members due to natural or unnatural reasons like earthquake or corrosion. One of the methods used from the early in last decade to recognize damage is wavelet
Ali Mohammad Rousta   +3 more
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Anisotropic dynamics in a shaken granular dimer gas experiment

open access: yes, 2004
The dynamics, velocity fluctuations, and particle-plate interactions for a 2D granular gas of shaken, non-spherical particles are studied experimentally. The experiment consists of a horizontal plate that is vertically oscillated to drive the dynamics of
Atwell, J., Olafsen, J. S.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Restraining mechanism [PDF]

open access: yes, 1970
A restraining mechanism restraining a pressurized garment so as to limit its ballooning effect is described. A helically wound spring is bonded at its outer periphery to an elongated flat plate which permits the flat plate to bend in a single direction ...
Hardy, J. C.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Fully articulated four-point-bend loading fixture [PDF]

open access: yes, 1991
A fully articulated four-point bend loading fixture for Modulus of Rupture (MOR) and fracture toughness specimens utilizes an upper loading plate in combination with a lower loading plate.
Calomino, Anthony M.
core   +1 more source

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