Results 61 to 70 of about 871,347 (297)

Bending Analysis of Thick Isotropic Plates by Using 5th Order Shear Deformation Theory [PDF]

Journal of Applied and Computational Mechanics, 2016
A 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate.
Yuwaraj M. Ghugal, Param D. Gajbhiye
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Hydration interactions: aqueous solvent effects in electric double layers

, 2000
A model for ionic solutions with an attractive short-range pair interaction between the ions is presented. The short-range interaction is accounted for by adding a quadratic non-local term to the Poisson-Boltzmann free energy.
A. P. Lyubartsev, A. P. Lyubartsev, B. Honig, B. V. Derjaguin, C. W. Outhwaite, D. Andelman, D. B. Lukatsky, D. E. Smith, D. Harries, D. L. Chapman, David Andelman, E. Guàrdia, E. Guàrdia, E. J. W. Verwey, F. Otto, G. Gouy, G. J. Fleer, G. M. Torrie, G. S. Manning, H. Greberg, I. Borukhov, I. Borukhov, J. Israelachvili, J. Israelachvili, J. K. Percus, J. L. Barrat, L. D. Landau, L. Guldbrand, L. Lue, M. J. Stevens, M. N. Tamashiro, P. Debye, P. Debye, R. Kjellander, R. Kjellander, R. Kjellander, R. Kjellander, R. M. Pashley, R. M. Pashley, R. R. Netz, R. R. Netz, S. Alexander, S. L. Carnie, S. Levine, S. Marc̆elja, S. Marc̆elja, S. Marc̆elja, S. Marc̆elja, T. Morita, Yoram Burak   +49 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Casimir effect for curved geometries: PFA validity limits

, 2006
We compute Casimir interaction energies for the sphere-plate and cylinder-plate configuration induced by scalar-field fluctuations with Dirichlet boundary conditions.
H. B. G. Casimir, Holger Gies, K. A. Milton, Klaus Klingmüller, R. L. Jaffe   +4 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Comment on ‘Fully covariant radiation force on a polarizable particle’

New Journal of Physics, 2014
Recently Pieplow and Henkel (2013 New J. Phys. http://dx.doi.org/10.1088/1367-2630/15/2/023027 15 http://dx.doi.org/10.1088/1367-2630/15/2/023027 ) presented a new fully covariant theory of the Casimir friction force acting on small neutral particle ...
A I Volokitin, B N J Persson
doaj   +1 more source

A nth-order shear deformation theory for composite laminates in cylindrical bending

Curved and Layered Structures, 2015
The present study investigates whether an nthorder shear deformation theory is applicable for the composite laminates in cylindrical bending. The theory satisfies the traction free conditions at top and bottom surfaces of the plate and does not require ...
Sayyad A. S., Ghugal Y. M.
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source