Results 11 to 20 of about 1,198,051 (418)

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Journal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe, Chaitanya Pandit, Chikkamenahalli Lakshminarayana Lakshmikanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Cletus Joseph Michael D'Souza   +5 more
doaj   +2 more sources

Platelet activating factor in allergies

International Journal of Immunopathology and Pharmacology, 2015
The platelet-activating factor (PAF) produced and released by mast cells, basophils, neutrophils, eosinophils, fibroblasts, platelets, endothelial cells, and even cardiac muscle cells plays an important role in inflammatory and thrombotic diseases. PAF has been shown to be an important mediator in anaphylaxis. Serum level of the factor correlates with
K. Pałgan, Z. Bartuzi
semanticscholar   +4 more sources

Platelet-activating Factor

Japanese Journal of Thrombosis and Hemostasis, 1991
血 小 板 活 性 化 因 子(platelet-activating factor, PAF)は,現 在 の と こ ろ唯 一 非 常 に 強 力 な 生 理 活 性 を持 つ リン脂 質 で あ り,そ の 本 体 は ア ル キ ル エ ー テ ル 型 コ リ ン リ ン脂 質(1-0-alkyl2-acetyl-sn-glycero-3-phosphocholine, alkylacetyl-GPCho)で あ る(Fig.1).そ の 特 異 的 な構 造 の 一 つ で あ る ア ル キ ...
T. Kawasaki, Jun-ichi Kambayashi
semanticscholar   +4 more sources

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β(1-42) [PDF]

Journal of Neuroinflammation, 2004
BACKGROUND: Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β(1-42 )or the prion protein).
Bate, Clive, Salmona, Mario, Williams, Alun   +2 more
core   +4 more sources

Impact of targeting the platelet-activating factor and its receptor in cancer treatment. [PDF]

Mil Med Res
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Qaderi K, Shahmoradi A, Thyagarajan A, Sahu RP.   +3 more
europepmc   +2 more sources

PAF Physiology in Target Organ Systems—A Deep Dive to Understand the PAF Mystery in Pathogenesis of Disease

Hearts, 2021
The purpose of this literature review is to gain an overview of the role of platelet-activating factor (PAF) within each of the body systems and how it contributes to normal and pathophysiological states.
Nilank Shah, Karan Kumar, Nikeith Shah
doaj   +1 more source

The Platelet-Activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine

Cells, 2021
The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla   +14 more
doaj   +1 more source

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment

Frontiers in Immunology, 2022
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
Timothy C. Frommeyer, Michael M. Gilbert, Garrett V. Brittain, Tongfan Wu, Trang Q. Nguyen, Craig A. Rohan, Craig A. Rohan, Craig A. Rohan, Jeffrey B. Travers, Jeffrey B. Travers, Jeffrey B. Travers   +10 more
doaj   +1 more source

Platelet activating factor

Ensho, 1981
Susumu Otomo
openalex   +4 more sources

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

Cardiogenetics, 2022
Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure.
Nilank Shah, Roshni Sethi, Sachin Shah, Komail Jafri, Jonah Duran, Yong Chang, Chirag Soni, Hanna Wollocko   +7 more
doaj   +1 more source