Results 221 to 230 of about 257,216 (264)

Platelet Activating Factor Receptors

2003
Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
Sanaa Choufani, Sylvie G. Bernier, Alfredo Ribeiro-da-Silva, Annie Bourdeau, A. Marilise Marrache, Fernand Gobeil, Martin G. Sirois, Ghassan Bkaily, Jean-Sébastien Joyal, Li Fan, Sylvain Chemtob, Daya R. Varma, Marek Rola-Pleszezynski, Jana Stankova, János G. Filep, Alejandro Vazquez-Tello   +15 more
openaire   +3 more sources

Synthesis of platelet-activating factor by human monocytes stimulated by platelet-activating factor

Journal of Allergy and Clinical Immunology, 1991
The capacity of platelet-activating factor (PAF) to stimulate its own synthesis by human monocytes was examined. Adherent human monocytes of greater than 85% purity were incubated with 100 fM to 10 nM of PAF in the presence of 20 microCi of [3H]acetic acid to radiolabel newly synthesized PAF.
Frank H. Valone, Frank H. Valone
openaire   +3 more sources

Platelet-Activating Factor

1995
Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
openaire   +2 more sources

Platelet-activating factor in human endometrium

The Journal of Steroid Biochemistry and Molecular Biology, 1994
Platelet-activating factor (PAF) is a phospholipid actively produced by human endometrium and deeply involved in the processes of ovoimplantation and labor. We recently found that PAF represents a new autocrine growth factor for a human adenocarcinoma cell line, HEC-1A.
BALDI, ELISABETTA, BONACCORSI, LORELLA, G. Finetti, M. Luconi, MURATORI, MONICA, SUSINI, TOMMASO, FORTI, GIANNI, SERIO, MARIO, MAGGI, MARIO   +8 more
openaire   +5 more sources

Role for Platelet-Activating Factor in Asthma

Lipids, 1991
AbstractRecent studies of the effects of platelet‐activating factor (PAF) on huan and animal airways would support a putative role for this lipid mediator in asthma. PAF can induce many aspects of the clinical and pathological features seen in asthmatic airways such as airway oedema, eosinophil accumulation in the airway wall, and bronchial ...
Kian Fan Chung, Peter J. Barnes
openaire   +2 more sources

Embryo-derived platelet activating factor

Reproduction, Fertility and Development, 1988
Platelet-activating factor (PAF) is secreted by the preimplantation embryo of a number of species. The role of this secretion is yet to be fully elucidated. Evidence to date indicates that it has an important function as an autocrine stimulant of embryonic metabolism, growth and viability. Production of PAF by embryos appears to be severely compromised
C. O’Neill, N. Spinks
openaire   +3 more sources

Cardiovascular Effects of Platelet-Activating Factor

Lipids, 1991
AbstractSudden release of platelet‐activating factor (PAF) into the circulation can cause hypotension, tachycardia, and circulatory collapse. To further examine this response, we performed detailed studies of cardiovascular function after PAF administration to young domestic pigs and newborn piglets.
Nancy J. Davenport, Giora Feuerstein, Joseph J. Stambouly, Robert E. Goldstein, Francisco R.M. Laurindo, Linda M. Bradley   +5 more
openaire   +3 more sources

Platelet-activating factor acetylhydrolase

Prostaglandins & Other Lipid Mediators, 2002
Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
openaire   +3 more sources

A superfusion bioassay for platelet-activating factor

Canadian Journal of Physiology and Pharmacology, 1989
A superfusion bioassay for platelet-activating factor is described using various types of tissues. By washing the tissue with 0.1–0.5% bovine serum albumin for 2–3 min after each addition of platelet-activating factor, desensitization did not develop in most tissues studied.
CIRINO, GIUSEPPE, J. L. Wallace
openaire   +4 more sources

Platelet-Activating Factor

2016
Platelet-activating factor (PAF) is a phospholipid produced by a variety of cells including platelets, endothelial cells, neutrophils, monocytes and macrophages. It has a wide range of potent biological activities including wound healing, physiological inflammation, apoptosis, angiogenesis, reproduction and long-term potentiation.
openaire   +2 more sources