Results 241 to 250 of about 4,500,208 (289)
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Hospital Practice, 1983
Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator.
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Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator.
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Scandinavian Journal of Gastroenterology, 1996
Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Platelet-activating factor (PAF) is a proinflammatory lipid. It has been strongly implicated in the regulation of pancreatic exocrine secretion and in the local and systemic events which occur in acute pancreatitis. PAF antagonists, when given as pretreatment, ameliorate the severity of experimental acute pancreatitis by reducing serum amylase ...
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Platelet-activating factor and asthma
Journal of Allergy and Clinical Immunology, 1988anaphylaxis. And if you research into the 1920s) there a very useful treatment in blocking both thrombocyare articles, particularly in the German literature, that topenia and some of the features of anaphylaxis. The report thrombocytopenia as being a feature of clinical first article (1924) stated that heparin totally prevents asthma.
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Platelet-Activating Factor Antagonists
Annual Review of Pharmacology and Toxicology, 1987Over the past decade platelet-activating factor has achieved the status of an important inflammatory mediator. The scientific enthusiasm and number of research investigators, publications, and meetings recently devoted to PAF suggest that this mediator will be the subject of continued study in the foreseeable future.
R N, Saunders, D A, Handley
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Platelet-Activating Factor and Platelet-Activating Factor Antagonists in Acute Pancreatitis
Digestive Surgery, 1999<i>Introduction:</i> Acute pancreatitis causes platelet-activating factor (PAF) to be released which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF has also been implicated as a key mediator in the progression of severe acute pancreatitis, which can lead to complications and unacceptably
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Platelet Activating Factor and Conception
American Journal of Reproductive Immunology, 1996PURPOSE: This review provides evidence for the involvement of platelet activating factor (PAF) in the several facets of pregnancy establishment.METHODS: A comprehensive literature review and new data.RESULTS: PAF has a role in spermatozoal function, fertilization, embryo development, and implantation.CONCLUSIONS: PAF is intimately involved in ...
B S, Minhas +5 more
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Platelet-Activating Factor and Angiogenesis
1996Platelet-activating factor (PAF) is a phospholipid autacoid with a spectrum of diverse and potent biological properties relevant for the development of inflammatory reaction and septic shock1. Recently, PAF has been also implicated in the embryogenesis and cell differentiation2,3. Researchers believe that PAF is a mediator of cell to cell communication
CAMUSSI, Giovanni +4 more
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Platelet Activating Factor Receptors
2003Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache +15 more
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Role for Platelet-Activating Factor in Asthma
Lipids, 1991AbstractRecent studies of the effects of plateletâactivating factor (PAF) on huan and animal airways would support a putative role for this lipid mediator in asthma. PAF can induce many aspects of the clinical and pathological features seen in asthmatic airways such as airway oedema, eosinophil accumulation in the airway wall, and bronchial ...
K F, Chung, P J, Barnes
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Cardiovascular Effects of Platelet-Activating Factor
Lipids, 1991AbstractSudden release of plateletâactivating factor (PAF) into the circulation can cause hypotension, tachycardia, and circulatory collapse. To further examine this response, we performed detailed studies of cardiovascular function after PAF administration to young domestic pigs and newborn piglets.
R E, Goldstein +5 more
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