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Seminal Platelet-Activating Factor
Seminars in Thrombosis and Hemostasis, 2007Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues.
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Pathobiology of Platelet-Activating Factors
Pathology and Immunopathology Research, 2008Throughout the evolution of knowledge about inflammation, a primary goal has been to understand this important biological response in sufficient depth to prevent the unwanted tissue injury that may spontaneously occur or that may coevolve to produce disease.
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Synthesis of platelet-activating factor by human monocytes stimulated by platelet-activating factor
Journal of Allergy and Clinical Immunology, 1991The capacity of platelet-activating factor (PAF) to stimulate its own synthesis by human monocytes was examined. Adherent human monocytes of greater than 85% purity were incubated with 100 fM to 10 nM of PAF in the presence of 20 microCi of [3H]acetic acid to radiolabel newly synthesized PAF.
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Revue Française d'Allergologie et d'Immunologie Clinique, 1977
Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
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Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
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2000
Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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Platelet-activating factor receptor
Journal of Lipid Mediators and Cell Signalling, 1995T, Izumi +6 more
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1995
Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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