Results 41 to 50 of about 1,198,051 (418)

Hypoxia-inducible Factor-dependent Regulation of Platelet-activating Factor Receptor as a Route for Gram-Positive Bacterial Translocation across Epithelia

Molecular Biology of the Cell, 2010
Results from these studies reveal that some strains of Gram-positive bacteria exploit hypoxia-inducible factor-regulated platelet-activating factor receptor as a means for translocation through intestinal epithelial cells.
S. Keely, L. Glover, T. Weissmueller, C. Macmanus, S. Fillon, B. Fennimore, S. Colgan   +6 more
semanticscholar   +1 more source

Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable ...
Ayla Eser, Ilknur Inegol Gumus, Husamettin Erdamar, Ikbal Kaygusuz, Melahat Yildirim, Betul Usluogullari, Muzeyyen Duran Erdolu, Serap Aynur Simavli, Ramazan Yigitoglu, Nilgun Ozturk Turhan   +9 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy [PDF]

, 2019
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Andrade, Luciana Nogueira de Sousa, Chammas, Roger, Jancar, Sonia, Silva Junior, Ildefonso Alves da   +3 more
core   +1 more source

Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. [PDF]

, 2000
Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell-mediated renal injury was assessed in murine crescentic glomerulonephritis (GN).
Bernatowicz, Bohm, Bradford, Connolly, Cunningham, Erlich, Grandaliano, Holdsworth, Huang, Ishihara, Kahn, Li, Mari, Mueller, Naish, Neale, Nicholson, Nystedt, Rasmussen, Rydel, Shankar, Stone, Taylor, Taylor, Thomson, Tipping, Tipping, Tipping, Ueno, Vu, Vu, Woolkalis, Xu, Xu   +33 more
core   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils.

Journal of Clinical Investigation, 1986
Platelet-activating factor (PAF-acether), an inflammatory mediator with a wide range of biological activities including neutrophil aggregation and chemotaxis, was studied for its effect on human eosinophil locomotion (chemotaxis and chemokinesis).
A. Wardlaw, R. Moqbel, O. Cromwell, A. Kay   +3 more
semanticscholar   +1 more source

Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. [PDF]

, 2018
Platelet-activating factor (PAF) is a potent phospholipid mediator that exerts various pathophysiological effects by interacting with a G protein-coupled receptor.
Abood, Mary E., Barlow, Christine L., Brailoiu, Eugen, Brailoiu, G. Cristina, Ramirez, Servio H.   +4 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source