Results 91 to 100 of about 24,574 (253)

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Berberich, Nina, Bihari, Peter, Khandoga, Alexander G., Krombach, Fritz, Lerchenberger, Max, Rehberg, Markus, Reichel, Christoph A., Zahler, Stefan   +7 more
core   +1 more source

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source

Sex‐Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo‐Inositol Supplementation During Suckling

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This graphical abstract illustrates the effects of myo‐inositol supplementation during suckling in reducing long‐term metabolic impacts from mild gestational calorie restriction (GCR). Using a metabolomics approach, 164 metabolites were identified, with greater metabolic alterations in males.
Rocío A. Martín‐Chamorro, Jean‐Charles Martin, Pedro Castillo, Mariona Palou, Andreu Palou, Ana María Rodríguez, Catalina Picó   +6 more
wiley   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

Rare but relevant: Cannabis use and myocardial infarction

Addiction, Volume 120, Issue 12, Page 2580-2584, December 2025.
Abstract Pre‐clinical research and case reports have linked cannabis use to myocardial infarction (MI) since the 1970s. The association with MI may be specific to certain types and patterns of cannabis use as well as certain consumer characteristics; however, due to limited data availability, meta‐analyses examining the association between cannabis use
Prianka Padmanathan, Emmert Roberts
wiley   +1 more source

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia

Molecular Therapy: Nucleic Acids, 2014
Well-differentiated human airway epithelia present formidable barriers to efficient siRNA delivery. We previously reported that treatment of airway epithelia with specific small molecules improves oligonucleotide uptake and facilitates RNAi responses ...
Sateesh Krishnamurthy, Mark A Behlke, Michael A Apicella, Paul B McCray, Jr, Beverly L Davidson   +4 more
doaj   +1 more source

Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration. [PDF]

, 2010
BACKGROUND: An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission.
Bate, Clive, Tayebi, Mourad, Williams, Alun   +2 more
core   +1 more source

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. [PDF]

, 2014
RATIONALE: Acute respiratory distress syndrome (ARDS) affects over 200000 people annually in the USA. Despite causing severe, and often refractory, hypoxaemia, the high mortality and long-term morbidity of ARDS results mainly from extra-pulmonary organ ...
Balan, KK, Chilvers, Edwin R, Johnston, Andrew, Mackenzie, Iain M, Peters, A Michael, Singh, Nanak R, Solanki, Chandra, Summers, Charlotte, White, Jessica F   +8 more
core   +4 more sources

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source

First-Row Transition Metal Complexes Incorporating the 2-(2'-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin. [PDF]

Molecules, 2023
Margariti A, Papakonstantinou VD, Stamatakis GM, Demopoulos CA, Machalia C, Emmanouilidou E, Schnakenburg G, Nika MC, Thomaidis NS, Philippopoulos AI.   +9 more
europepmc   +1 more source