Results 161 to 170 of about 4,406,154 (211)
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Platelet activating factor (PAF) and lyso-PAF in psoriasis
Archives of Dermatological Research, 1994Previous studies have shown that scale from lesional psoriatic skin contains substantial amounts of platelet activating factor (PAF). In this study, PAF and its immediate precursor, lyso-PAF, were measured in exudates from abrasions on lesional and uninvolved psoriatic skin, and from skin of healthy subjects.
M R, Judge +5 more
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Procoagulant property of platelet activating factor (PAF)
Agents and Actions, 1993Platelet-activating factor (PAF) is known to activate platelets and thus promote clot formation in most mammalian species including humans. In this communication, the ability of PAF to hasten the overall coagulation process by measuring the recalcification time (RT) is described.
G W, Raff +3 more
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The specificity of the binding of platelet activating factor (PAF) to anti‐PAF antibodies
Journal of Molecular Recognition, 1990AbstractQuantitative hapten inhibition experiments employing sheep anti‐PAF antibodies and selected PAF analogues were undertaken with the aim of defining the antigenic determinant structures complementary to the antibody combining sites. The most important fine structural features for inhibition of antibody binding to PAF were shown to be an acetyl ...
M A, Smal, B A, Baldo, D G, Harle
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Release, purification, and characterization of platelet-activating factor (PAF)
Biochimie, 1980Platelet-activating factor (PAF) is a phospholipid mediator, released by basophils, macrophages and neutrophils under immunological and non immunological stimuli. It aggregates platelets and liberates their vasoactive contents. We studied the "spontaneous" release of PAF from hog blood leukocytes : optimal conditions were 22 degrees C, pH 9.5 in BSA ...
V, Tencé +3 more
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PLATELET-ACTIVATING FACTOR (PAF) IN EXPERIMENTAL AND CLINICAL SEPSIS
Shock, 1997Despite considerable progress in understanding the pathogenic mechanisms of Gram-negative sepsis, the outcome of septic patients has not significantly improved. There are ample data that support a role for inflammatory mediators in sepsis that act in synergy with infectious agents to initiate and propagate the disease process.
G, Mathiak +4 more
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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Immunofluorescent localization of platelet-activating factor (PAF) in the rat
The Histochemical Journal, 1993An immunofluorescent staining method for detecting platelet-activating factor (PAF) is described. This method employs a polyclonal anti-PAF rabbit antibody. When rat brain, heart, lung, liver or kidney tissue was stained using this method, the heart, lung and kidney exhibited PAF-specific staining.
Y, Hirashima +5 more
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A specific, sensitive radioimmunoassay for platelet-activating factor (PAF)
Journal of Immunological Methods, 1990A specific radioimmunoassay (RIA) has been developed for platelet-activating factor (PAF) and shown to be sensitive over the range 10-1000 pg (0.02-2 pmol). The anti-PAF antibodies showed specificity for the acetyl group at the C2 position of the PAF molecule and exhibited no significant cross-reactivity with lyso-PAF or the naturally occurring lipids ...
M A, Smal, B A, Baldo, A, McCaskill
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Structural analogs of platelet-activating factor (PAF-acether)
Biochimie, 1981Platelet-activafing factor (PAF-acether) is a potent mediator of anaphylaxis and inflammation. It induces aggregation of platelets mad releases their vasoactive amines. PAF-acether has' been shown to be produced by basophils [1, 2], macrophages [3, 4], neutrophils [51, and platelets themselves [6].
M, Tence +5 more
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Aggregation of equine platelets by PAF (platelet-activating factor)
Inflammation, 1983Platelet-activating factor (PAF), a lipid released as a result of immediate allergic reactions from basophils and mast cells as well as by a variety of other cell types and stimuli, is one of the most potent platelet agonists and hypotensive agents known. Equine platelets stimulated over a wide range of PAF concentrations aggregated in a time- and dose-
C M, Suquet, R W, Leid
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