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Plasma platelet activating factor-acetylhydrolase (PAF-AH)
Progress in Lipid Research, 2003The platelet-activating factor-acetylhydrolase (PAF-AH) is an enzyme which catalyzes the hydrolysis of acetyl ester at the sn-2 position of PAF. The family of PAF-AHs consists of two intracellular isoforms (Ib and II), and one secreted isoform (plasma). These PAF-AHs show different biochemical characteristics and molecular structures. Plasma PAF-AH and
Ken, Karasawa +4 more
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Platelet-activating factor (PAF) and PAF antagonists in asthma.
Critical reviews in therapeutic drug carrier systems, 1991PAF is produced by and activates inflammatory cells, such as monocytes/macrophages, mast cells, platelets, neutrophils, eosinophils and endothelial cells. Its ability to imitate anaphylaxis, inducing for instance bronchoconstriction (BC) in guinea-pigs, and its identification (and/or that of lyso-PAF) in exudates from shocked lungs, led to the ...
D, Hosford +2 more
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Molecular modeling on platelet‐activating factor (PAF) and new proposed PAF antagonists
International Journal of Quantum Chemistry, 1996Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells.
Carlos M. R. De Sant'anna +4 more
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Rabbit blastocysts accumulate platelet‐activating factor (PAF) and lyso‐PAF in vitro
Molecular Reproduction and Development, 1992AbstractPlatelet‐activating factor (1‐O‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and has been demonstrated to bind specifically to rabbit uterine ...
M A, Jones, G B, Kudolo, M J, Harper
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Platelet-activating factor (PAF-acether): Present status
Agents and Actions, 1981PAF-acether, first discovered in 1971-72, is now recognized as a 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine released from various cells and organs, including macrophages, neutrophils, platelets, the kidney and heart. In this review, we will concentrate on the newest aspects of PAF-acether biochemistry and pathophysiology: (1) PAF-acether is ...
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The Role of Platelet-Activating Factor (PAF) in Experimental Glomerular Injury
Lipids, 1991AbstractPlatelet‐activating factor (PAF) is a potent autacoid that participates in inflammation and other pathophysiological processes. In this review we deal with recent evidence suggesting that PAF is a mediator that is released early during glomerular injury. PAF can be synthesized in the glomerulus by infiltrating intrinsic glomerular cells. Normal
A, Ortiz +4 more
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Inhibitor(s) of Platelet-Activating Factor (PAF) in Human Saliva
Lipids, 1991AbstractQuantitation of platelet‐activating factor (PAF) in human saliva samples by radioimmunoassay indicated there was, at times, sufficient PAF present to aggregate platelets. However, in certain samples, we observed little or no aggregation, and furthermore, these samples were found to inhibit aggregation induced by PAF (200 pg).
M A, Smal, B A, Baldo
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Mucosal dysfunction and damage induced by platelet activating factor (PAF)
Acta Oto-Laryngologica, 1990The effect of PAF on human nasal mucosa was investigated in vitro. Normal paranasal sinus mucosa was obtained from the ethmoid sinuses by surgical procedure and incubated in the form of tissue culture. Ciliary movement was viewed under an inverted microscope and recorded on video tapes, and its activity was measured photoelectrically.
T, Ganbo, K, Hisamatsu
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Tritiated hexadecyl platelet activating factor (PAF)
Journal of Labelled Compounds and Radiopharmaceuticals, 1985AbstractWe report the synthesis of the natural isomer of [3H]‐lyso platelet activating factor, [3H]‐lyso PAF (1‐0‐[9′,10′‐3H2]‐hexadecyl‐2‐lyso‐sn‐glycero‐3‐phosphocholine) and its conversion by acetylation to [3H]‐PAF(1‐0‐[9′,10′‐3H2]‐hexadecyl‐2‐acetylsn‐glycero‐3‐phosphocholine) for use in in vitro and in vivo metabolic studies.
Steven D. Wyrick +3 more
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