Results 231 to 240 of about 5,437,630 (278)

Platelet-activating factor receptor

Prostaglandins and Other Lipid Mediators, 2002
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was named for its potential to induce platelet aggregation, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues.
Takao Shimizu, Satoshi Ishii, Takahide Nagase   +2 more
exaly   +4 more sources

Platelet-activating factor receptor

Trends in Pharmacological Sciences, 1996
The human platelet-activating factor receptor gene exists as a single copy on chromosome 1. Two 5'-noncoding exons (Exon 1 and 2) has distinct transcription initiation sites and promoters. These exons are alternatively spliced to a common splice acceptor site on exon 3 that contains a total coding regions.
T, Shimizu, H, Mutoh, S, Kato
  +5 more sources

Platelet-activating factor receptor

Journal of Lipid Mediators and Cell Signalling, 1995
Motonao Nakamura, Haruhiko Bito, Takashi Izumi   +2 more
exaly   +3 more sources

Organization of Porcine Platelet‐Activating Factor Receptor Gene

Animal Biotechnology, 2003
Four exons of porcine platelet-activating factor receptor (PAFr) gene expressing transcript 1 and transcript 2 were determined previously. In this study, we cloned and sequenced a new exon, which also initiates transcript 2, and determined the order of 5 exons in the PAFr gene.
William E Roudebush
exaly   +3 more sources

Platelet Activating Factor Receptors

2003
Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache, Fernand, Gobeil, Sylvie G, Bernier, Jana, Stankova, Marek, Rola-Pleszczynski, Sanaa, Choufani, Ghassan, Bkaily, Annie, Bourdeau, Martin G, Sirois, Alejandro, Vazquez-Tello, L, Fan, Jean-Sebastien, Joyal, Janos G, Filep, Daya R, Varma, Alfredo, Ribeiro-Da-silva, Sylvain, Chemtob   +15 more
openaire   +2 more sources

Binding of carbamyl-platelet-activating factor to the raji lymphoblast platelet-activating factor receptor

International Journal of Immunopharmacology, 1992
Carbamyl-platelet-activating factor (1-hexadecyl-2-N-methylcarbamyl-glycero-3-phosphocholine; CPAF) is an analog of platelet-activating factor (PAF) containing an N-methylcarbamyl moiety at the sn-2 position. CPAF was tested for effects on the Raji lymphoblast PAF receptor.
J B, Travers, Q, Li, H, Sprecher, R H, Fertel   +3 more
openaire   +2 more sources

Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils

European Journal of Pharmacology: Molecular Pharmacology, 1994
We investigated the effects of the platelet activating factor (PAF) receptor antagonists, SM-12502 ((+)-cis-3,5-dimethyl-2-(pyridyl)- thiazolidin-4-one hydrochloride), WEB-2086 (3-(4-(2-chlorphenyl)-9-methyl-6H-thieno(3,2-f)-(1,2,4)triazolo(4, 3- a)(1,4)diazepin-2-yl)-1-(4-morpholinyl)-1-propanone) and RP-48740 (3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c ...
H, Koike, N, Imanishi, Y, Natsume, S, Morooka   +3 more
openaire   +2 more sources

Species difference in the specific receptors of platelet activating factor

Biochemical Pharmacology, 1986
Relative potencies of platelet activating factor (PAF) and PAF analogs and several PAF receptor antagonists when inhibiting the [3H]PAF specific binding to human and rabbit platelet membranes and membrane fragments of human lung tissues were compared.
S B, Hwang, M H, Lam
openaire   +2 more sources

Characterization of platelet-activating factor receptors in porcine platelets

Canadian Journal of Physiology and Pharmacology, 1990
Despite a large number of studies describing the properties and effects of platelet-activating factor (PAF), little is known about its receptor structure. The characterization of the PAF receptor from additional cell types and species is important for the design of strategies to purify and characterize the receptor molecule.
V, Duronio, A, Reany, S, Wong, C, Bigras, H, Salari   +4 more
openaire   +2 more sources

Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune Diseases

Inflammation & Allergy - Drug Targets, 2009
Platelet activating factor (PAF) is a phospholipid mediator of inflammation that is released early in inflammation by a variety of cell types. PAF acts largely by binding to its receptor, PAF-R, a G-protein coupled receptor found on a variety of cells, including cells of the immune system.
Laura J, Edwards, Cris S, Constantinescu
openaire   +2 more sources