Results 251 to 260 of about 158,362 (293)
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Inflammation & Allergy - Drug Targets, 2009
Platelet activating factor (PAF) is a phospholipid mediator of inflammation that is released early in inflammation by a variety of cell types. PAF acts largely by binding to its receptor, PAF-R, a G-protein coupled receptor found on a variety of cells, including cells of the immune system.
Laura J, Edwards, Cris S, Constantinescu
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Platelet activating factor (PAF) is a phospholipid mediator of inflammation that is released early in inflammation by a variety of cell types. PAF acts largely by binding to its receptor, PAF-R, a G-protein coupled receptor found on a variety of cells, including cells of the immune system.
Laura J, Edwards, Cris S, Constantinescu
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Receptor-dependent internalization of platelet-activating factor.
The Journal of Immunology, 1994Abstract A human neutrophil platelet-activating factor (PAF) receptor expressed in transfected cells was utilized to study receptor-dependent interactions with the ligand. This receptor displays ligand-binding properties comparable with those observed with naturally occurring receptor-positive cells when binding experiments are performed
N P, Gerard, C, Gerard
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Characterization of platelet-activating factor receptors in porcine platelets
Canadian Journal of Physiology and Pharmacology, 1990Despite a large number of studies describing the properties and effects of platelet-activating factor (PAF), little is known about its receptor structure. The characterization of the PAF receptor from additional cell types and species is important for the design of strategies to purify and characterize the receptor molecule.
V, Duronio +4 more
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The FASEB Journal, 2013
Platelet‐activating factor receptor (PAFR)‐deficient mice developed a more severe obese state characterized by higher body mass (~25%) and epididymal fat mass (~55%) with age than that of wild‐type (WT) littermates. PAFR‐deficient mice did not show changes in the expression of critical genes involved in anabolic and catabolic ...
Junko, Sugatani +12 more
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Platelet‐activating factor receptor (PAFR)‐deficient mice developed a more severe obese state characterized by higher body mass (~25%) and epididymal fat mass (~55%) with age than that of wild‐type (WT) littermates. PAFR‐deficient mice did not show changes in the expression of critical genes involved in anabolic and catabolic ...
Junko, Sugatani +12 more
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Structure and Regulation of Platelet Activating Factor Receptor Gene
1997Platelet-activating factor (PAF) is not only a potent proinflammatory compound, but also plays important roles in reproductive, gastrointestinal, neuronal, respiratory systems (Hanahan, 1986; Barnes et al., 1988; Prescott et al., 1990; Bazan, 1994; Snyder, 1995; Izumi and Shimizu, 1995).
T, Shimizu, H, Mutoh
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Receptors | Platelet-Activating Factor Receptor
2021Katherine M. Howard, Justin J. Miller
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[Stroke, platelet activating factor and receptor antagonists].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019Stroke is an acute cerebrovascular disease with high morbidity, disability and mortality. The prevention and treatment conditions for stroke is severe all over the world. Antiplatelet aggregation is an effective treatment. Platelet activation factor (PAF) is another important medium in mediating platelet aggregation, which plays an important role in ...
Zhi-Guo, Wang +4 more
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Platelet-activating factor receptor
Journal of Lipid Mediators and Cell Signalling, 1995T, Izumi +6 more
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Multiple Signaling Pathways for Platelet-Activating Factor Receptor
Physiology, 1992Platelet-activating factor (PAF) receptor is coupled to multiple signaling pathways, including phospholipid turnover via phospholipases C, D, A2;Ca2+ mobilization;and activation of protein kinase C and tyrosine kinase. The cloned receptor shows homology to G protein-coupled receptors.
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