Results 281 to 290 of about 160,257 (342)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

The Interconnected World of Coagulation Factors, Platelets and Plasminogen: A Novel Perspective on Biosynthetic Regulation. [PDF]

Life (Basel)
Bergo I, Slevin M, Pastorello Y, Höhne A, Tero-Vescan A.   +4 more
europepmc   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Salvia miltiorrhiza: insights on the protective effect and mechanism of myocardial ischemia-reperfusion injury. [PDF]

Braz J Med Biol Res
Lan Q, Chen L, Chen MT, Wan ZX, Peng T, Mazhar M, Liu P, Luo G, Jiang Y, Liu MN.   +9 more
europepmc   +1 more source

Platelets as central hubs of inflammation. [PDF]

Front Immunol
Bo Y, Zhao F.
europepmc   +1 more source

The Crucial Roles of Platelets as Immune Mediators in Sepsis. [PDF]

J Inflamm Res
Yang X, Song J, Ma H, Hua N, Bai Y, Ju Y, Shen JW, Zheng W, Jiang S.   +8 more
europepmc   +1 more source

T cells in ITP: Focus on T follicular helper cells and cytotoxic T cells. [PDF]

Br J Haematol
Audia S, Cooper N.
europepmc   +1 more source

Cancer-Associated Thrombosis (CAT); mechanisms and treatment options. [PDF]

Thromb J
Alshehri FS, Alloghbi A, Alshalani A, Sabah HA, Whyte CS.   +4 more
europepmc   +1 more source

Coronary microcirculatory dysfunction after percutaneous coronary intervention: pathogenesis, diagnosis, and therapeutic strategies. [PDF]

Front Cardiovasc Med
BoYuan J, TingTing W, ChengJun H, XinYi H, YuShan C.   +4 more
europepmc   +1 more source

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Platelet activating factor receptor

Trends in Pharmacological Sciences, 1996
The human platelet-activating factor receptor gene exists as a single copy on chromosome 1. Two 5'-noncoding exons (Exon 1 and 2) has distinct transcription initiation sites and promoters. These exons are alternatively spliced to a common splice acceptor site on exon 3 that contains a total coding regions.
T, Shimizu, H, Mutoh, S, Kato
  +5 more sources