Results 291 to 300 of about 160,257 (342)

Platelet-activating factor receptor

Prostaglandins & Other Lipid Mediators, 2002
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was named for its potential to induce platelet aggregation, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues.
Zen-ichiro, Honda, Satoshi, Ishii, Takao, Shimizu   +2 more
openaire   +3 more sources

Binding of carbamyl-platelet-activating factor to the raji lymphoblast platelet-activating factor receptor

International Journal of Immunopharmacology, 1992
Carbamyl-platelet-activating factor (1-hexadecyl-2-N-methylcarbamyl-glycero-3-phosphocholine; CPAF) is an analog of platelet-activating factor (PAF) containing an N-methylcarbamyl moiety at the sn-2 position. CPAF was tested for effects on the Raji lymphoblast PAF receptor.
J B, Travers, Q, Li, H, Sprecher, R H, Fertel   +3 more
openaire   +2 more sources

Platelet Activating Factor Receptors

2003
Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache, Fernand, Gobeil, Sylvie G, Bernier, Jana, Stankova, Marek, Rola-Pleszczynski, Sanaa, Choufani, Ghassan, Bkaily, Annie, Bourdeau, Martin G, Sirois, Alejandro, Vazquez-Tello, L, Fan, Jean-Sebastien, Joyal, Janos G, Filep, Daya R, Varma, Alfredo, Ribeiro-Da-silva, Sylvain, Chemtob   +15 more
openaire   +2 more sources

Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils

European Journal of Pharmacology: Molecular Pharmacology, 1994
We investigated the effects of the platelet activating factor (PAF) receptor antagonists, SM-12502 ((+)-cis-3,5-dimethyl-2-(pyridyl)- thiazolidin-4-one hydrochloride), WEB-2086 (3-(4-(2-chlorphenyl)-9-methyl-6H-thieno(3,2-f)-(1,2,4)triazolo(4, 3- a)(1,4)diazepin-2-yl)-1-(4-morpholinyl)-1-propanone) and RP-48740 (3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c ...
H, Koike, N, Imanishi, Y, Natsume, S, Morooka   +3 more
openaire   +2 more sources

Characterization of platelet-activating factor receptors in porcine platelets

Canadian Journal of Physiology and Pharmacology, 1990
Despite a large number of studies describing the properties and effects of platelet-activating factor (PAF), little is known about its receptor structure. The characterization of the PAF receptor from additional cell types and species is important for the design of strategies to purify and characterize the receptor molecule.
V, Duronio, A, Reany, S, Wong, C, Bigras, H, Salari   +4 more
openaire   +2 more sources

Species difference in the specific receptors of platelet activating factor

Biochemical Pharmacology, 1986
Relative potencies of platelet activating factor (PAF) and PAF analogs and several PAF receptor antagonists when inhibiting the [3H]PAF specific binding to human and rabbit platelet membranes and membrane fragments of human lung tissues were compared.
S B, Hwang, M H, Lam
openaire   +2 more sources

Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune Diseases

Inflammation & Allergy - Drug Targets, 2009
Platelet activating factor (PAF) is a phospholipid mediator of inflammation that is released early in inflammation by a variety of cell types. PAF acts largely by binding to its receptor, PAF-R, a G-protein coupled receptor found on a variety of cells, including cells of the immune system.
Laura J, Edwards, Cris S, Constantinescu
openaire   +2 more sources

Structure and Regulation of Platelet Activating Factor Receptor Gene

1997
Platelet-activating factor (PAF) is not only a potent proinflammatory compound, but also plays important roles in reproductive, gastrointestinal, neuronal, respiratory systems (Hanahan, 1986; Barnes et al., 1988; Prescott et al., 1990; Bazan, 1994; Snyder, 1995; Izumi and Shimizu, 1995).
T, Shimizu, H, Mutoh
openaire   +2 more sources

Localization of Platelet-Activating Factor Receptor in the Rat Brain

1997
Platelet-activating factor (PAF) has diverse effects on various cells and tissues despite its initial characterization as an activator of platelets (Braquet et al., 1987; Izumi and Shimizu, 1995). PAF is involved in a wide variety of events in the central nervous system (CNS).
M, Mori, M, Aihara, K, Kume, M, Hamanoue, S, Kohsaka, T, Shimizu   +5 more
openaire   +2 more sources

Receptor-dependent internalization of platelet-activating factor.

The Journal of Immunology, 1994
Abstract A human neutrophil platelet-activating factor (PAF) receptor expressed in transfected cells was utilized to study receptor-dependent interactions with the ligand. This receptor displays ligand-binding properties comparable with those observed with naturally occurring receptor-positive cells when binding experiments are performed
N P, Gerard, C, Gerard
openaire   +2 more sources