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Receptors | Platelet-Activating Factor Receptor

Encyclopedia of Biological Chemistry III, 2021
Katherine M. Howard, Justin J. Miller
openaire   +2 more sources

Antiobese function of platelet‐activating factor: increased adiposity in platelet‐activating factor receptor‐deficient mice with age

The FASEB Journal, 2013
Platelet‐activating factor receptor (PAFR)‐deficient mice developed a more severe obese state characterized by higher body mass (~25%) and epididymal fat mass (~55%) with age than that of wild‐type (WT) littermates. PAFR‐deficient mice did not show changes in the expression of critical genes involved in anabolic and catabolic ...
Junko, Sugatani   +12 more
openaire   +3 more sources

Platelet activating factor receptor

Trends in Pharmacological Sciences, 1996
The human platelet-activating factor receptor gene exists as a single copy on chromosome 1. Two 5'-noncoding exons (Exon 1 and 2) has distinct transcription initiation sites and promoters. These exons are alternatively spliced to a common splice acceptor site on exon 3 that contains a total coding regions.
T, Shimizu, H, Mutoh, S, Kato
  +5 more sources

Platelet-activating factor receptor

Prostaglandins & Other Lipid Mediators, 2002
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was named for its potential to induce platelet aggregation, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues.
Zen-ichiro, Honda   +2 more
openaire   +3 more sources

Platelet Activating Factor Receptors

2003
Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache   +15 more
openaire   +2 more sources

Binding of carbamyl-platelet-activating factor to the raji lymphoblast platelet-activating factor receptor

International Journal of Immunopharmacology, 1992
Carbamyl-platelet-activating factor (1-hexadecyl-2-N-methylcarbamyl-glycero-3-phosphocholine; CPAF) is an analog of platelet-activating factor (PAF) containing an N-methylcarbamyl moiety at the sn-2 position. CPAF was tested for effects on the Raji lymphoblast PAF receptor.
J B, Travers   +3 more
openaire   +2 more sources

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