Results 321 to 330 of about 433,927 (377)

Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils

European Journal of Pharmacology: Molecular Pharmacology, 1994
We investigated the effects of the platelet activating factor (PAF) receptor antagonists, SM-12502 ((+)-cis-3,5-dimethyl-2-(pyridyl)- thiazolidin-4-one hydrochloride), WEB-2086 (3-(4-(2-chlorphenyl)-9-methyl-6H-thieno(3,2-f)-(1,2,4)triazolo(4, 3- a)(1,4)diazepin-2-yl)-1-(4-morpholinyl)-1-propanone) and RP-48740 (3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c ...
H, Koike, N, Imanishi, Y, Natsume, S, Morooka   +3 more
openaire   +2 more sources

Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune Diseases

Inflammation & Allergy - Drug Targets, 2009
Platelet activating factor (PAF) is a phospholipid mediator of inflammation that is released early in inflammation by a variety of cell types. PAF acts largely by binding to its receptor, PAF-R, a G-protein coupled receptor found on a variety of cells, including cells of the immune system.
Laura J, Edwards, Cris S, Constantinescu
openaire   +2 more sources

Receptor-dependent internalization of platelet-activating factor.

The Journal of Immunology, 1994
Abstract A human neutrophil platelet-activating factor (PAF) receptor expressed in transfected cells was utilized to study receptor-dependent interactions with the ligand. This receptor displays ligand-binding properties comparable with those observed with naturally occurring receptor-positive cells when binding experiments are performed
N P, Gerard, C, Gerard
openaire   +2 more sources

Characterization of platelet-activating factor receptors in porcine platelets

Canadian Journal of Physiology and Pharmacology, 1990
Despite a large number of studies describing the properties and effects of platelet-activating factor (PAF), little is known about its receptor structure. The characterization of the PAF receptor from additional cell types and species is important for the design of strategies to purify and characterize the receptor molecule.
V, Duronio, A, Reany, S, Wong, C, Bigras, H, Salari   +4 more
openaire   +2 more sources

Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis.

Journal of Immunology, 1998
Recent studies suggest that the lipid mediator platelet-activating factor (PAF) is involved in keratinocyte function and skin inflammation. Indeed, PAF is found in association with inflammatory skin diseases, intradermal injections of PAF induce ...
Y. Pei, Lisa A. Barber, R. Murphy, Christopher Johnson, S. W. Kelley, L. Dy, R. Fertel, Thanh Minh Nguyen, David A. Williams, J. Travers   +9 more
semanticscholar   +1 more source

Structure and Regulation of Platelet Activating Factor Receptor Gene

1997
Platelet-activating factor (PAF) is not only a potent proinflammatory compound, but also plays important roles in reproductive, gastrointestinal, neuronal, respiratory systems (Hanahan, 1986; Barnes et al., 1988; Prescott et al., 1990; Bazan, 1994; Snyder, 1995; Izumi and Shimizu, 1995).
T, Shimizu, H, Mutoh
openaire   +2 more sources

Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice

Progress in Lipid Research, 2000
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was initially recognized for its potential to induce platelet aggregation and secretion, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues, many of
S, Ishii, T, Shimizu
openaire   +2 more sources

[Stroke, platelet activating factor and receptor antagonists].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Stroke is an acute cerebrovascular disease with high morbidity, disability and mortality. The prevention and treatment conditions for stroke is severe all over the world. Antiplatelet aggregation is an effective treatment. Platelet activation factor (PAF) is another important medium in mediating platelet aggregation, which plays an important role in ...
Zhi-Guo, Wang, Dan-Qiao, Wang, Yue, Jiao, Xin, Tian, Ming-Yu, Sun   +4 more
openaire   +1 more source

Platelet-activating factor receptor

Journal of Lipid Mediators and Cell Signalling, 1995
T, Izumi, T, Takano, H, Bito, M, Nakamura, H, Mutoh, Z, Honda, T, Shinizu   +6 more
openaire   +2 more sources

Structural basis for signal recognition and transduction by platelet-activating-factor receptor

Nature Structural & Molecular Biology, 2018
C. Cao, Q. Tan, Chanjuan Xu, Lingli He, Linlin Yang, Ye Zhou, Yiwei Zhou, A. Qiao, Min-Giang Lu, C. Yi, G. Han, Xianping Wang, Xuemei Li, Huaiyu Yang, Z. Rao, Hualiang Jiang, Yongfang Zhao, Jianfeng Liu, R. Stevens, Qiang Zhao, Xuejun C. Zhang, Beili Wu   +21 more
semanticscholar   +1 more source