Results 1 to 10 of about 173,886 (267)
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]
Proceedings of the National Academy of Sciences, 2010 Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after ...
P. Charles Lin +5 more
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Role of Platelet-Derived Growth Factors in the Testis [PDF]
Endocrine Reviews, 2010 Normal development and function of the testis are controlled by endocrine and paracrine signaling pathways. Platelet-derived growth factors (PDGFs) are growth factors that mediate epithelial-mesenchymal interactions in various tissues during normal and abnormal processes such as embryo development, wound healing, tissue fibrosis, vascular disorders ...
BASCIANI, Sabrina +3 more
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Platelet-Derived Growth Factor C in Alcoholics
Alcohol and Alcoholism, 2020 Abstract Aims Platelet-derived growth factor (PDGF) promotes liver collagen deposition, acting on hepatic stellate cells. Despite this, low serum PDGF levels were reported in chronic hepatitis C or B infection, although some studies yield the opposite result.
L González-Navarrete +8 more
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Journal of Biological Chemistry, 1982 Two homobifunctional cross-linking reagents have been used to cross-link 125I-platelet-derived growth factor (PDGF) to a cell surface component with an approximate Mr = 164,000 that has many characteristics of a specific PDGF receptor. Excess unlabeled PDGF competed for labeling of this component, while high concentrations of fibroblast growth factor ...
K Glenn, D F Bowen-Pope, Russell Ross
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Platelet-derived Growth Factors and Receptors in Canine Lymphoma [PDF]
Journal of Comparative Pathology, 2014 Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibitors in the treatment of several ...
ARICO', ARIANNA +8 more
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Platelet-derived growth factor and mesangial cells
Kidney International, 1992 Growth factors and cytokines such as the platelet-derived growth factor (PDGF) have the potential to mediate many biologic responses of glomerular cells, particularly mesangial cells [1]. Peptide growth factors including PDGF possess diverse biologic properties highly relevant to glomerular pathology [2].
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Platelet-derived growth factor in chemotactic for fibroblasts. [PDF]
The Journal of cell biology, 1982 Chemotaxis assays in modified Boyden chambers were used to detect fibroblast chemoattractants in materials released from early-stage inflammatory cells, namely, mast cells, platelets, and neutrophils. Strong attractant activity was found in substances released from platelets. This activity was accounted for mainly by the platelet-derived growth factor (
Elliott Schiffmann +4 more
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Purification of human platelet-derived growth factor. [PDF]
Proceedings of the National Academy of Sciences, 1979 Human platelets contain a polypeptide growth factor that stimulates the proliferation of connective tissue cells. Purification of this platelet-derived growth factor (PDGF) was accomplished by heat (100 degrees C) treatment of washed platelets and subsequent ion-exchange chromatography, gel filtration in 1 M acetic acid, isoelectric focusing, and ...
Charles D. Scher +2 more
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Purification of a growth factor related to platelet-derived growth factor and a type β transforming growth factor secreted by mouse neuroblastoma cells. A general strategy for the purification of basic polypeptide growth factors [PDF]
, 1989 A.J.M. van den Eijnden-van Raaij +6 more
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Platelet-derived growth factor promotes polymorphonuclear leukocyte activation [PDF]
, 1984 DY Tzeng +5 more
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