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PET imaging of platelet derived growth factor receptor β in lung fibrosis [PDF]

open access: yesEJNMMI Radiopharmacy and Chemistry
Background Lung diseases such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are associated with significant morbidity and mortality, with limited treatment options.
Olivia Wegrzyniak   +11 more
doaj   +2 more sources

Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity [PDF]

open access: yesMolecular Medicine
Background Pericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and energy metabolism
Akira Okekawa   +7 more
doaj   +2 more sources

Inhibition and Mechanism of Imatinib on A549 Xenograft Tumor in Nude Mice via PDGF/PDGFR Pathway

open access: yesZhongliu Fangzhi Yanjiu, 2023
Objective To investigate the effect of imatinib on the growth of A549 non-small cell lung cancer transplanted tumors and the expression of PDGFB and PDGFRβ proteins in tumor tissues and stroma in nude mice and to explore the underlying tumor suppression ...
XIA Bingtian   +6 more
doaj   +1 more source

Evaluation of factors affecting the quantity and quality of platelet-rich plasma and platelet-derived growth factor-BB

open access: yesCHRISMED Journal of Health and Research, 2021
Context: Platelet-rich plasma (PRP) releases growth factors (GFs) upon activation which accelerates the healing and regeneration in the target tissue. Wider applications of PRP warrant product standardization.
Rahul Verma   +4 more
doaj   +1 more source

Platelet-Rich Plasma: Quantitative Assessment of Growth Factor Levels and Comparative Analysis of Activated and Inactivated Groups [PDF]

open access: yesArchives of Plastic Surgery, 2013
BackgroundPlatelet-rich plasma (PRP) has more concentrated platelets than normal plasma (approximately 150-400×103 cell/dL). Platelets excrete several growth factors and cytokines that are associated with the healing and regeneration process.
Jeong Woo Lee   +8 more
doaj   +3 more sources

PDGF-BB homodimer serum level – a good indicator of the severity of alcoholic liver cirrhosis

open access: yesAnnals of Agricultural and Environmental Medicine, 2020
Introduction Liver cirrhosis is a chronic disease in which progressive fibrosis is noted. This process leads to changed architectonics of the liver parenchyma and the appearance of regenerative nodules, all of which are caused by pathological activation ...
Ewa Kurys-Denis   +5 more
doaj   +1 more source

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

open access: yesPulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu   +21 more
doaj   +1 more source

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