Results 141 to 150 of about 173,886 (267)

Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer. [PDF]

Front Pharmacol
Khalid H, Sattar F, Ahmad I, Junior VFP, Nishan U, Ullah R, Dib H, Omari KW, Shah M.   +8 more
europepmc   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Abelson murine leukemia virus induces platelet-derived growth factor-independent fibroblast growth: correlation with kinase activity and dissociation from full morphologic transformation.

, 1989
R W Rees-Jones, M Goldfarb, S P Goff
openalex   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Inhibition of myotube formation by platelet-derived growth factor subunit B in QM7 cells. [PDF]

Anim Biosci
Choi S, Shin S.
europepmc   +1 more source

Comparative studies on the biological activity of the human platelet vascular permeability factor(HVPF) and platelet-derived growth factor(PDGF).

, 1988
Joji IMURA, Hitoshi Niino, Yoshihiro Ashihara, Nariyoshi Hoshikawa, Kenjiro Shirasawa   +4 more
openalex   +2 more sources

Characterization of the tyrosine phosphorylation of calpactin I (annexin II) induced by platelet-derived growth factor [PDF]

, 1991
Riccardo Brambilla, Renata Zippel, E. Sturani, Laura Morello, António M. Peres, Lilia Alberghina   +5 more
openalex   +1 more source

Platelet-derived Growth Factor Signaling

Reactome - a curated knowledgebase of biological pathways, 2009
openaire   +2 more sources

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Platelet-Derived Growth Factor Subunit A Strengthens the Neurovascular Unit and Inhibits Retinal Vascular Regression Under Hyperoxic Conditions. [PDF]

Int J Mol Sci
Yokota K, Yamada H, Mori H, Hattori Y, Omi M, Yamamoto Y, Toyama K, Imai H.   +7 more
europepmc   +1 more source