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Platelet-derived growth factor
Molecular and Cellular Endocrinology, 1985Platelet-derived growth factor (PDGF) is a family of isoforms that stimulate the growth, survival, and motility of fibroblasts, smooth muscle cells, and other cell types (reviewed in ref. 1) (Fig. 1). PDGF was originally identified in human platelets and purified from this source; however, subsequent studies have shown that PDGF is synthesized by a ...
Arne Östman +2 more
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Platelet‐derived growth factor.
Cell Biology International, 1995ABSTRACTPlatelet‐derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. Two different PDGF chains termed A and B encoded by different genes have been identified leading to three different PDGF isoforms, the AA and BB homodimers and the AB heterodimer.
W Meyer-Ingold, W Eichner
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The platelet-derived growth factor
Cell, 1978The platelet is well known for its importance in the process of blood coagulation and hemostasis. However, only in recent years has it become apparent that this cell also plays an important role in the process of inflammation and in the stimulation of cell proliferation.
Arthur M. Vogel, Russell Ross
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Platelet-derived growth factors
Blood Reviews, 1989Blood platelets are a rich source of growth factors, including platelet-derived growth factor, platelet-derived endothelial cell growth factor, and transforming growth factor beta. Platelet-derived growth factor stimulates the growth of mesenchymal cells such as fibroblasts and vascular smooth muscle cells, whereas platelet-derived endothelial cell ...
Kohei Miyazono, Fumimaro Takaku
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Platelet‐derived growth factor in asthma
Allergy, 1995Platelet‐derived growth factor (PDGF) controls cellular growth, migration, and differentiation. It is secreted by various cell types, including macrophages, and participates in tissue repair and epithelial regeneration. PDGF may therefore be involved in airway remodeling in asthma.
P. Vic +5 more
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PLATELET-DERIVED GROWTH FACTOR
Annual Review of Medicine, 1987Platelet-derived growth factor (PDGF) is emerging as a key mitogen in an increasing range of biological events, far more wide-reaching than initially suspected. Purification of the molecule and development of an antibody to PDGF have enhanced our ability to study its interactions with cells and the capacity of cells to express the gene for PDGF ...
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Platelet-derived endothelial cell growth factor
Progress in Growth Factor Research, 1991AbstractPlatelet‐derived endothelial cell growth factor (PD‐ECGF) is a 45kDa single chain polypeptide which stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. Analysis of a full length PD‐ECGF cDNA revealed an open reading frame coding for 482 amino acids without homology to other known proteins. No signal sequence was
Carl-Henrik Heldin +2 more
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Journal of Oral Pathology & Medicine, 2008
Background: Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method: Twenty‐nine specimens of ...
Nikolaus Wick +3 more
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Background: Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method: Twenty‐nine specimens of ...
Nikolaus Wick +3 more
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The platelet-derived growth factor system
1989Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells in culture. PDGF was first recognized as a regulator of mesenchymal cell proliferation in the setting of vascular injury and wound healing [1,2]. It has become clear, however, that PDGF and its receptors (the PDGF system) play equally important roles in normal developmental
Mark T. Keating, Shaun R. Coughlin
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Current Opinion in Nephrology and Hypertension, 2004
The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
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The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
openaire +3 more sources