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8 Platelet-derived growth factor
Clinics in Endocrinology and Metabolism, 1984Platelet-derived growth factor (PDGF) is a basic (pI congruent to 10) 30 000 molecular weight protein circulating in normal blood sequestered within the platelet alpha-granules. It binds with high affinity (Kd = 10(-11) M) to a specific cell-surface receptor found on many connective tissue cell types in culture.
Daniel F. Bowen-Pope, Russell Ross
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Platelet‐derived growth factor in human glioma
Glia, 1995AbstractPlatelet‐derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide‐bonded dimers of A‐ and B‐chains. PDGF receptors are of two types, α‐ and β‐receptors, which are members of the protein‐tyrosine kinase family of receptors. The receptors are activated by ligand‐induced dimerization, whereby the receptors become phosphorylated on ...
Monica Nistér +2 more
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Platelet-Derived Growth Factor and the Skeleton
2002Publisher Summary This chapter focuses on the effects of platelet-derived growth factor (PDGF) on the skeleton. PDGFis a polypeptide with a molecular mass of 30 kDa, which is composed of two polypeptide chains, and may be combined in a homodimeric or heterodimeric form.
Sheila Rydziel, Ernesto Canalis
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Platelet-derived growth factor in Dupuytren's disease
The Journal of Hand Surgery, 1992This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical ...
Marie A. Badalamente +3 more
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Developmental roles of platelet‐derived growth factors
BioEssays, 2001AbstractPlatelet‐derived growth factor (PDGF) was originally identified in platelets and in serum as a mitogen for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. PDGF has since expanded to a family of dimers of at least four gene products, whose biological actions are mediated through two receptor tyrosine kinases, PDGFRs.
Linda Karlsson +2 more
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Platelet-derived growth factor in experimental glomerulonephritis
Nephrology Dialysis Transplantation, 1995Growth factors and in particular platelet-derived growth factor (PDGF) have been implicated in the pathogenesis of glomerulonephritis and glomerulosclerosis. We have studied the distribution of immunoreactive PDGF (iPDGF) within serial kidney biopsies (days 7, 15, 30, 90 and 120) of eight rats with an accelerated form of nephrotoxic serum nephritis ...
A. M. El Nahas, Gexiang Zhang
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Atherosclerosis and platelet derived growth factors
1993Coronary heart disease (CHD) accounts for more than 160,000 deaths per year in England and Wales [1], and is the major cause of mortality of men under 65 years of age in the Western world. The economic impact of CHD is correspondingly profound, with estimated costs for treating the condition in England and Wales alone exceeding £400 million per annum ...
C Rutherford, Gordon A. Ferns
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Platelets, platelet-derived growth factor and arteriosclerosis
Experientia, 1988Platelets participate in the pathogenesis of arteriosclerosis and in the progression of atherosclerosis by adhering to the damaged arteries and subsequently forming mural thrombi which are either swept away and embolize or are endothelialized and thus become part of the vessel wall. Rheologic considerations predict and blood perfusion experiments using
M. Hosang, H. R. Baumgartner
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Platelet-derived growth factor and renal disease
Current Opinion in Nephrology & Hypertension, 2012This review focuses on the recent advances in our understanding of the role of platelet-derived growth factor (PDGF) in glomerular disease.Accumulating evidence indicates a critical involvement of PDGF receptor-β (PDGFR-β) signaling in glomerular disease. Augmented signaling via PDGFR-β is involved in the pathogenesis of IgA nephropathy.
Masakiyo Sasahara +2 more
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Platelet-derived growth factor and malignant transformation
Biochemical Pharmacology, 1984Investigations of human platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal derived cells in culture [l-3], have provided a rational basis for the understanding of at least one mechanism involved in malignant transformation. PDGF is a heat-stable (loo”), cationic (isolectric point 9.8) polypeptide [4] that circulates in blood stored
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