Results 21 to 30 of about 346,819 (347)

Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target

Frontiers in Pharmacology, 2020
Asthma is a chronic and heterogenic disease of the respiratory system, one of the most common lung diseases worldwide. The underlying pathologies, which are chronic inflammatory process and airway remodeling (AR), are mediated by numerous cells and ...
Grzegorz Kardas, Agnieszka Daszyńska-Kardas, Mateusz Marynowski, Oliwia Brząkalska, Piotr Kuna, Michał Panek   +5 more
doaj   +1 more source

PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India

Tumor Biology, 2017
Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. Platelet-derived growth factor receptor-α is a tyrosine kinase and a side target for imatinib, a revolutionary drug for the treatment of chronic ...
Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena   +8 more
doaj   +1 more source

Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury

Neural Regeneration Research, 2021
The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the ...
Lu-Xia Ye, Ning-Chen An, Peng Huang, Duo-Hui Li, Zhi-Long Zheng, Hao Ji, Hao Li, Da-Qing Chen, Yan-Qing Wu, Jian Xiao, Ke Xu, Xiao-Kun Li, Hong-Yu Zhang   +12 more
doaj   +1 more source

Effect of recombinant human platelet-derived growth factor-BB-coated sutures on Achilles tendon healing in a rat model: A histological and biomechanical study

Journal of Tissue Engineering, 2012
Purpose: Repairing tendon injuries with recombinant human platelet-derived growth factor-BB has potential for improving surgical outcomes. Augmentation of sutures, a critical component of surgical tendon repair, by coating with growth factors may provide
Stephen H Cummings, Daniel A Grande, Christopher K Hee, Hans K Kestler, Colleen M Roden, Neil V Shah, Pasquale Razzano, David M Dines, Nadeen O Chahine, Joshua S Dines   +9 more
doaj   +1 more source

Macrophage lipoprotein lipase expression is increased in patients with heterozygous familial hypercholesterolemia

Journal of Lipid Research, 2002
FH is associated with accelerated atherosclerosis. Based on the crucial role of macrophage LPL in atherogenesis, we determined in the present study macrophage LPL expression in patients with FH.
Marie-Claude Beauchamp, Élaine Letendre, Geneviève Renier   +2 more
doaj   +1 more source

A comparative profile of total protein and six angiogenically-active growth factors in three platelet products

GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, 2022
Objectives: Platelet-derived products have been shown as promising novel therapeutic agents for chronic wounds. However, their clinical use requires a greater degree of method standardisation, part of which involved more extensive cataloguing of their ...
Custo, Scott, Baron, Byron, Felice, Alex, Seria, Elisa   +3 more
doaj   +1 more source

A Study of the PDGF Signaling Pathway with PRISM [PDF]

, 2011
In this paper, we apply the probabilistic model checker PRISM to the analysis of a biological system -- the Platelet-Derived Growth Factor (PDGF) signaling pathway, demonstrating in detail how this pathway can be analyzed in PRISM.
A. Aziz, A. Gutiérrez-Uzquiza, A. L. Reddi, A. Regev, A. Sadot, C. A. Joazeiro, C. E. Bazenet, C.-H. Heldin, D. Hanahan, E. M. Hahn, Erik de Vink, F. Ciocchetta, G. Krauss, Ion Petre, J. Cools, J. Fisher, J. Fisher, J. Heath, J. Krivine, J. Yu, J. Yu, Jun Pang, K. Anan, K. Yokote, M. Miettinen, M. Schwarick, M. Tallquist, M. Z. Kwiatkowska, M. Z. Kwiatkowska, M. Z. Kwiatkowska, M. Z. Kwiatkowska, Monique Wiesinger, N. Bonzanni, N. Bonzanni, P. Drábik, Panuwat Trairatphisan, Qixia Yuan, S. Hart, S. K. Jha, S. Valgeirsdóttir, Sjouke Mauw, T. Han, T. R. Golub, Thomas Sauter, U.S. Bhalla   +44 more
core   +3 more sources

MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha

Respiratory Research, 2021
Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia ...
Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan, Charitharth Vivek Lal   +10 more
doaj   +1 more source

SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]

, 2009
CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M., Cushley, W., Edkins, A.L., Ozanne, B.W.   +3 more
core   +2 more sources

Hyaluronic acid induces the release of growth factors from platelet-rich plasma

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2016
Background/Objective: Platelet-rich plasma (PRP) and hyaluronic acid (HA) injection are both therapeutic options for osteoarthritis and chronic tendinopathy.
Kohei Iio, Ken-Ichi Furukawa, Eiichi Tsuda, Yuji Yamamoto, Shugo Maeda, Takuya Naraoka, Yuka Kimura, Yasuyuki Ishibashi   +7 more
doaj   +1 more source