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Platelet-derived growth factor
Molecular and Cellular Endocrinology, 1985Platelet-derived growth factor (PDGF) is a family of isoforms that stimulate the growth, survival, and motility of fibroblasts, smooth muscle cells, and other cell types (reviewed in ref. 1) (Fig. 1). PDGF was originally identified in human platelets and purified from this source; however, subsequent studies have shown that PDGF is synthesized by a ...
C H, Heldin, A, Wasteson, B, Westermark
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Platelet‐derived growth factor.
Cell Biology International, 1995ABSTRACTPlatelet‐derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. Two different PDGF chains termed A and B encoded by different genes have been identified leading to three different PDGF isoforms, the AA and BB homodimers and the AB heterodimer.
W, Meyer-Ingold, W, Eichner
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Platelet-derived growth factors
Blood Reviews, 1989Blood platelets are a rich source of growth factors, including platelet-derived growth factor, platelet-derived endothelial cell growth factor, and transforming growth factor beta. Platelet-derived growth factor stimulates the growth of mesenchymal cells such as fibroblasts and vascular smooth muscle cells, whereas platelet-derived endothelial cell ...
K, Miyazono, F, Takaku
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The platelet-derived growth factor
Cell, 1978The platelet is well known for its importance in the process of blood coagulation and hemostasis. However, only in recent years has it become apparent that this cell also plays an important role in the process of inflammation and in the stimulation of cell proliferation.
R, Ross, A, Vogel
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Platelet-derived endothelial cell growth factor
Progress in Growth Factor Research, 1991AbstractPlatelet‐derived endothelial cell growth factor (PD‐ECGF) is a 45kDa single chain polypeptide which stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. Analysis of a full length PD‐ECGF cDNA revealed an open reading frame coding for 482 amino acids without homology to other known proteins. No signal sequence was
K, Miyazono, K, Usuki, C H, Heldin
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PLATELET-DERIVED GROWTH FACTOR
Annual Review of Medicine, 1987Platelet-derived growth factor (PDGF) is emerging as a key mitogen in an increasing range of biological events, far more wide-reaching than initially suspected. Purification of the molecule and development of an antibody to PDGF have enhanced our ability to study its interactions with cells and the capacity of cells to express the gene for PDGF ...
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