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Signal transduction via platelet-derived growth factor receptors
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules.
Arne Östman +2 more
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Structural and functional aspects of the receptors for platelet-derived growth factor
Progress in Growth Factor Research, 1989Platelet-derived growth factor (PDGF) is a 30 kDa dimer of disulfide-bonded A and B chains. Three isoforms of PDGF have been isolated (PDGF-AA, PDGF-AB and PDGF-BB). These bind with different affinities and specificities to two structurally related cell surface receptors, viz. the alpha-receptor and the beta-receptor.
Lena Claesson-Welsh +2 more
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Regulation of chemotaxis by the platelet-derived growth factor receptor-β
Nature, 1994Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly understood. Platelet-derived growth factor (PDGF) acts both as a mitogen and a chemoattractant. Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a ...
Sue Goo Rhee +6 more
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Caveolin Is an Inhibitor of Platelet-Derived Growth Factor Receptor Signaling
Experimental Cell Research, 1999Caveolin is a major structural component of caveolae and has been implicated in the regulation of the function of several caveolae-associated signaling molecules. Platelet-derived growth factor (PDGF) receptors and caveolin were colocalized in the same subcellular fraction after sucrose density gradient fractionation of fibroblasts.
Yoshihiro Ishikawa +3 more
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Current Opinion in Nephrology and Hypertension, 2004
The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
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The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
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Receptors for platelet-derived growth factor on microvascular endothelial cells
1992Endothelial cells are widely thought to be unresponsive to platelet-derived growth factor (PDGF) and devoid of PDGF receptors. However, in examining the growth factor responses of microvascular endothelial cells isolated from human omental adipose tissue, we detected PDGF-induced tyrosine phosphorylation of an 180-kD glycoprotein, subsequently ...
Frackelton Ar +3 more
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Platelet-Derived Growth Factor B Type Receptor
1990Platelet-derived growth factor (PDGF) is a major mitogen in serum for connective tissue cells (for reviews, see Heldin et al., 1985; Ross et al., 1986). The in vivo function of PDGF is not known. However, the fact that PDGF is released from platelets in conjunction with the blood coagulation and stimulates not only proliferation, but also chemotaxis ...
Lars Rönnstrand, Carl-Henrik Heldin
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Modulation of Epidermal Growth Factor Receptors on 3T3 Cells by Platelet-Derived Growth Factor
Science, 1980Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors.
CF Fox, M Wrann, Russell Ross
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Diabetes, 1996
Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino +8 more
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Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino +8 more
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Role of KIT and platelet-derived growth factor receptors as oncoproteins
Seminars in Oncology, 2004KIT and platelet-derived growth factor receptors (PDGFRs) play critical oncogenic roles in a broad spectrum of hematologic and solid tumors. These receptor tyrosine kinases, as well as ABL and BCR-ABL, are inhibited by imatinib. Tumors caused by chromosomal translocations that lead to overexpression of PDGFR ligand, resulting in continuous activation ...
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