The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]
, 2016 A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai +5 more
core +4 more sources
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]
, 2016 Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica +5 more
core +3 more sources
Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]
, 2002 Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E. +3 more
core +1 more source
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz +37 more
core +1 more source
Digoxin and platelet activation in patients with atrial fibrillation: In vivo and in vitro study [PDF]
, 2018 Background-Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation (AF). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation.
Bartimoccia, Simona +10 more
core +1 more source
Platelets, 2021 Platelets play an essential role in maintaining vascular integrity after injury. In addition, platelets contribute to the immune response to pathogens. For instance, they express receptors that mediate binding of viruses, and toll-like receptors that activate the cell in response to pathogen-associated molecular patterns.
Silvio Antoniak, Nigel Mackman
openaire +4 more sources
Microfluidic flow chambers using reconstituted blood to model hemostasis and platelet transfusion in vitro [PDF]
, 2016 Blood platelets prepared for transfusion gradually lose hemostatic function during storage. Platelet function can be investigated using a variety of (indirect) in vitro experiments, but none of these is as comprehensive as microfluidic flow chambers.
Compernolle, Veerle +4 more
core +2 more sources
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff +66 more
core +2 more sources
The Lancet, 2007 Ever since platelet transfusions were shown to reduce mortality from haemorrhage in patients with acute leukaemia in the 1950s, the use of this therapy has steadily grown to become an essential part of the treatment of cancer, haematological malignancies, marrow failure, and haematopoietic stem cell transplantation.
Stroncek, David F., Rebulla, Paolo
openaire +3 more sources