Results 11 to 20 of about 504,301 (176)

Prion protein fragment (106–126) activates NLRP3 inflammasome and promotes platelet-monocyte/neutrophil interactions, potentially contributing to an inflammatory state [PDF]

Frontiers in Cell and Developmental Biology
IntroductionPrion diseases are neurodegenerative disorders where infectious prion proteins (PrP) featuring an amyloidogenic amino acid sequence, PrP (106–126), accumulate in the brain leading to neuroinflammation while it can also access circulation by ...
Rashmi Verma, Jyotsna Kailashiya, Avijit Mukherjee, Rameshwar Nath Chaurasia, Debabrata Dash   +4 more
doaj   +2 more sources

On the Quest for In Vitro Platelet Production by Re-Tailoring the Concepts of Megakaryocyte Differentiation

Medicina, 2020
The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern.
Patricia Martínez-Botía, Andrea Acebes-Huerta, Jerard Seghatchian, Laura Gutiérrez   +3 more
doaj   +1 more source

Ayurvedic preparations of Raudra Rasa inhibit agonist‐mediated platelet activation and restrict thrombogenicity without affecting cell viability

FEBS Open Bio, 2023
Ayurveda is considered to be one of the most ancient forms of medicine still practiced. The Ayurvedic preparation Raudra Rasa and its derivatives have been widely employed against cancer since the 12th century, but the effect of these traditional ...
Susheel Nidhi Chaurasia, Vipin Singh, Mohammad Ekhlak, Manoj Kumar Dash, Namrata Joshi, Debabrata Dash   +5 more
doaj   +1 more source

Structure and thermodynamics of platelet dispersions [PDF]

Molec. Phys. 106, 1975 (2008), 2008
Various properties of fluids consisting of platelike particles differ from the corresponding ones of fluids consisting of spherical particles because interactions between platelets depend on their mutual orientations. One of the main issues in this topic is to understand how structural properties of such fluids depend on factors such as the shape of ...
arxiv   +1 more source

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors

Clinical and Applied Thrombosis/Hemostasis, 2019
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Valery Leytin PhD, Armen V. Gyulkhandanyan PhD, John Freedman MD   +2 more
doaj   +1 more source

Mutation spectrum and genotype‐phenotype correlations in a large French cohort of MYH9‐Related Disorders

Molecular Genetics & Genomic Medicine, 2014
MYH9‐Related Disorders are a group of rare autosomal dominant platelet disorders presenting as nonsyndromic forms characterized by macrothrombocytopenia with giant platelets and leukocyte inclusion bodies or as syndromic forms combining these ...
Béatrice Saposnik, Sylvie Binard, Odile Fenneteau, Alan Nurden, Paquita Nurden, Marie‐Françoise Hurtaud‐Roux, Nicole Schlegel, the French MYH9 network   +7 more
doaj   +1 more source

Dynamic Formation of Preferentially Lattice Oriented, Self Trapped Hydrogen Clusters [PDF]

arXiv, 2023
A series of MD and DFT simulations were performed to investigate hydrogen self-clustering and retention in tungsten. Using a newly develop machine learned interatomic potential, spontaneous formation of hydrogen platelets was observed after implanting low-energy hydrogen into tungsten at high fluxes and temperatures.
arxiv  

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source

Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity

Frontiers in Cell and Developmental Biology, 2022
Prion peptide (PrP) misfolds to infectious scrapie isoform, the β pleat-rich insoluble fibrils responsible for neurodegeneration and fatal conformational diseases in humans.
Deepa Gautam, Deepa Gautam, Jyotsna Kailashiya, Arundhati Tiwari, Rameshwar Nath Chaurasia, Gowtham K. Annarapu, Prasenjit Guchhait, Debabrata Dash   +7 more
doaj   +1 more source

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

Cell Communication and Signaling, 2018
Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens.
Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom   +2 more
doaj   +1 more source