Results 11 to 20 of about 1,682,982 (408)

An Insight into GPCR and G-Proteins as Cancer Drivers

Cells, 2021
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
Preeti Kumari Chaudhary, Soochong Kim
doaj   +1 more source

Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19

Journal of Medical Virology, 2020
Since December 2019, novel coronavirus infected pneumonia emerged in Wuhan city and rapidly spread throughout China. In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet‐to‐lymphocyte ...
Rong Qu, Y. Ling, Yi-huizhi Zhang, Li-ya Wei, Xiao Chen, Xu-ran Li, Xuan-yong Liu, Han-Mian Liu, Zhi Guo, H. Ren, Qiang Wang   +10 more
semanticscholar   +1 more source

Platelet activation.

Arteriosclerosis, 2020
Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the medium, and, with strong stimuli such as thrombin and PAF ...
Marjorie B. Zucker, V. Nachmias
semanticscholar   +1 more source

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
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Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]

, 2015
Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono), Jenie, I. M. (Ikhlas), Mulyono, B. (Budi), Soejono, S. K. (Sri)   +3 more
core   +2 more sources

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study

Platelets, 2020
Background Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear.
Yanli Liu, Wenwu Sun, Yanan Guo, Liangkai Chen, Lijuan Zhang, Su Zhao, Ding Long, Li Yu   +7 more
semanticscholar   +1 more source

In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect

Scientific Reports, 2017
Integrin αIIbβ3 mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), αIIbβ3 expression / function are impaired.
Matthieu Goguet, Tarun Jairaj Narwani, Rachel Petermann, Vincent Jallu, Alexandre G. de Brevern   +4 more
doaj   +1 more source