Results 21 to 30 of about 841,367 (303)

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard, Eichhorn, M. E.;Ney, L.;Massberg, S.;Goetz, A. E.   +4 more
core   +1 more source

Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]

, 2006
Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja, Kiefmann, Rainer, Dörger, Martina, Goetz, Alwin Eduard, Heckel, Kai   +4 more
core   +1 more source

On the Quest for In Vitro Platelet Production by Re-Tailoring the Concepts of Megakaryocyte Differentiation

Medicina, 2020
The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern.
Patricia Martínez-Botía, Andrea Acebes-Huerta, Jerard Seghatchian, Laura Gutiérrez   +3 more
doaj   +1 more source

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones

Cell Communication and Signaling, 2018
Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens.
Omar Elaskalani, Norbaini Binti Abdol Razak, Pat Metharom   +2 more
doaj   +1 more source

A megakaryocyte with no platelets: Anti-platelet antibodies, apoptosis, and platelet production

Platelets, 2012
Primary immune thrombocytopenia (ITP) and drug-induced thrombocytopenia (DITP) are disorders caused primarily by the presence of anti-platelet auto-antibodies (Abs). Hematologists have traditionally seen thrombocytopenia as the result of increased destruction of Ab-coated platelets by the reticuloendothelial system.
José, Perdomo, Feng, Yan, Beng H, Chong
openaire   +2 more sources

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

Selective degradation of platelet BTK by PROTAC NX-5948 provides antithrombotic benefits without affecting hemostasis

Blood Advances
: Current antithrombotic therapies are effective in reducing thrombotic events but are limited by their associated risk of bleeding. Bruton tyrosine kinase (BTK) acts as a key signaling switch that drives platelet activation during thrombosis but is ...
Carl J. May, Justin S. Trory, Connor E. Webb, Hetty S. Walker, Yong Li, Jonathan A. Furniss, Johannes A. Eble, Alastair W. Poole, Jordan Vautrinot, Jay Tromans, Ingeborg Hers   +10 more
doaj   +1 more source

Ayurvedic preparations of Raudra Rasa inhibit agonist‐mediated platelet activation and restrict thrombogenicity without affecting cell viability

FEBS Open Bio, 2023
Ayurveda is considered to be one of the most ancient forms of medicine still practiced. The Ayurvedic preparation Raudra Rasa and its derivatives have been widely employed against cancer since the 12th century, but the effect of these traditional ...
Susheel Nidhi Chaurasia, Vipin Singh, Mohammad Ekhlak, Manoj Kumar Dash, Namrata Joshi, Debabrata Dash   +5 more
doaj   +1 more source

Platelet-associated proteins detected in serum EVs.

, 2022
Platelet-associated proteins detected in serum EVs.
Akiko Takeda (31405), Hideki Mochizuki (204792), Xiaoman Zhang (1885492), Toshihide Takeuchi (115925), Yoshitaka Nagai (115940)   +4 more
core   +1 more source

Mutation spectrum and genotype‐phenotype correlations in a large French cohort of MYH9‐Related Disorders

Molecular Genetics & Genomic Medicine, 2014
MYH9‐Related Disorders are a group of rare autosomal dominant platelet disorders presenting as nonsyndromic forms characterized by macrothrombocytopenia with giant platelets and leukocyte inclusion bodies or as syndromic forms combining these ...
Béatrice Saposnik, Sylvie Binard, Odile Fenneteau, Alan Nurden, Paquita Nurden, Marie‐Françoise Hurtaud‐Roux, Nicole Schlegel, the French MYH9 network   +7 more
doaj   +1 more source