Results 221 to 230 of about 841,367 (303)

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Impaired α-Granule Secretion Dominates Longitudinal Agonist-Induced Platelet Dysfunction in Gaucher Disease. [PDF]

Int J Mol Sci
Revel-Vilk S, Zimran A, Dinur T, Frydman D, Shulman E, Benayoun E, Broide E, Naamad M, Koren N, Saltsman M.   +9 more
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Biological performance enhancement of Ni-free Zr-based bulk metallic glass for dental implants via nitrogen plasma immersion ion implantation. [PDF]

J Dent Sci
Huang HM, Sun YS, Huang YL, Lin KY, Porntaveetus T, Osathanon T, Chen WC, Huang HH.   +7 more
europepmc   +1 more source

Are Platelet Volume, Density, and the Homeostatic Blueprint the Missing Link in Platelet-Rich Plasma Therapies? An Evidence-Based Narrative Review. [PDF]

J Clin Med
Everts PA, Podesta L, Fitzpatrick J, Oliveira LP, Lana JF, van Zundert A, Sánchez M, Delgado D, Mahoney CB, Flanagan G, Alexander R, Harrison P.   +11 more
europepmc   +1 more source

Beyond the Numbers: A Practical Framework for Interpreting the Full Blood Count for Foundation Doctors. [PDF]

Cureus
Thomas RL.
europepmc   +1 more source

An Automated Microfluidic System for Haemostasis Assessment in Cirrhosis With Thrombocytopenia. [PDF]

Liver Int
Bitto N, Tosetti G, Tripodi A, Lecchi A, La Marca S, Padovan L, Scalambrino E, Clerici M, Caputo C, Lucà M, Primignani M, Fracanzani AL, Lampertico P, Peyvandi F, La Mura V.   +14 more
europepmc   +1 more source