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Platelets

The Lancet, 2000
Platelets, derived from megakaryocyte cytoplasm, have a critical role in normal haemostasis, and in thrombotic disorders. The development of megakaryocytes is controlled by thrombopoietin, which binds to c-mpl on the surface of platelets and megakaryocytes.
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Blood Platelets and Platelet Transfusions

Archives of Internal Medicine, 1961
The application of quantitative biological and biochemical methods to the study of the blood platelets has led to revolutionary developments in our understanding of these elusive structures. 1 Until recently platelets were often regarded as non-cellular in nature, although it has long been known that they are of cellular origin.
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Platelet Counting

2013
Platelet counting is a daily basic hematological analysis of crucial interest in many clinical situations. Historical manual techniques (phase-contrast microscopy) have been replaced by automated techniques (impedance or optical analyzers) more rapid and precise.
Salignac, Sylvain   +3 more
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Platelets and platelet disorders in Africa

Baillière's Clinical Haematology, 1992
Blood platelets, which are known to play important roles in normal vertebrate biology, are influenced by a variety of factors, the majority of which are acquired. In this chapter, attention is drawn to the need to re-examine one of the old accepted values in haematology, the normal platelet count.
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Status of Platelet Collection and Platelet Transfusion

Therapeutic Apheresis, 2001
Abstract: Platelet product derived from single donor plateletpheresis is required to reduce the risks of adverse reactions by blood transfusion. The objectives of this study are to evaluate the status of platelet collection and its efficacy by various kinds of plateletpheresis equipment and to assess the achievement of platelet transfusion by platelet ...
S, Omokawa   +9 more
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Selenium in platelets

Biological Trace Element Research, 1988
Blood and its main components are commonly used to detect states of selenium deficiency. In order to examine whether human platelets are able to provide better or additional information, improvements of the analytical method resulted in surprisingly narrow normal ranges for selenium and other mineral elements using neutron activation analysis (NAA) and
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Platelet calmodulin correlates with platelet turnover

European Journal of Haematology, 1990
Abstract: We measured the calmodulin content in platelets in 13 normal persons and in 62 patients with hematological diseases. The level of platelet calmodulin was higher in patients with idiopathic thrombocytopenic purpura (ITP), systemic lupus erythematosus, myeloproliferative disorders, acute leukemia in a recovery phase, aplastic anemia ...
N, Endoh   +4 more
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Platelet Formation, Platelet Density and Platelet Ageing

1990
Microscopic examination of both platelets and megakaryocytes shows them to vary widely in size and ultrastructure. This structural diversity was noted by early investigators (Bunting 1909) and interest in its origin and significance has continued to the present day.
K. G. Chamberlain   +2 more
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PLATELETS AS IMMUNOGENS

Vox Sanguinis, 1992
An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
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Platelet dose for prophylactic platelet transfusions

Expert Review of Hematology, 2010
Although guidelines exist to deal with some aspects of platelet transfusion practice, many important clinical issues have not been addressed in large randomized controlled trials (RCTs). Slichter et al. conducted a RCT of prophylactic platelet transfusions to determine the effects of the dose of platelets on clinical signs of bleeding, the use of ...
Joan, Cid, Miguel, Lozano
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