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Platelet Activity in Washed Platelet Concentrates
Anesthesia & Analgesia, 2004Life-threatening anaphylaxis or febrile nonhemolytic transfusion reactions after transfusion of platelet concentrates (PCs) is a serious clinical problem caused by the sensitizing of recipients to plasma components, such as immunoglobulin A, or by cytokines. There is a possible indication for washing of PCs in these thrombocytopenic patients.
Schoenfeld H +4 more
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Platelet aggregation and platelet-inhibiting drugs
Neurochemical Pathology, 1987Platelet function may cause a progression of central gray matter damage after cerebrospinal hemorrhage or trauma because of the thrombotic occlusion of injured vessels or a vasospasm induced by extravasated blood. It has therefore been suggested that antiplatelet drugs could limit the extent of the neurological lesions produced by a spinal trauma.
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Platelet Count and Platelet Stickiness in Rats
Thrombosis and Haemostasis, 1971SummaryIn rat, a transected tail vessel proved an adequate source of blood for platelet enumeration. When suspensions of rat blood in ammonium oxalate were rotated for 1 h a significant loss of platelets was observed. This platelet reduction rate (PRR), calculated as per cent of the pre-rotation count, showed individual constancy and inter-individual ...
O P, Grüner, G K, Endresen
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Platelets and platelet inhibitors in infective endocarditis
Current Infectious Disease Reports, 2002The pathogenesis of infective endocarditis depends on complex interactions between the causative pathogen, plasma proteins, platelets, and vascular endothelial cells. In addition to being the main target of bacteria in the initial stage of bacterial adherence to the endocardium, platelets now appear to play an important role in antimicrobial host ...
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Mechanism and control of platelet-platelet interactions
Microvascular Research, 1972Abstract With the technique of shadow-casting of whole platelets, it has been possible to observe both the very early events produced on the platelet surface by aggregating agents and what appears to be the entire process of platelet aggregation. It has been shown that a variety of aggregating agents and conditions such as ADP, thrombin, collagen ...
François M. Booyse +3 more
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Platelet aggregation by platelet-clumping substance
Thrombosis Research, 1974Abstract The platelet-clumping substance isolated from rabbit plasma by the authors aggregated washed rabbit platelets, while ADP did not. The presence of AMP or adenosine did not inhibit the appearance of platelet aggregation induced by the clumping substance.
H, Yamazaki +3 more
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The Platelet Count and Mean Platelet Volume
British Journal of Haematology, 1981Summary. The Coulter Model S‐Plus Counter provides a measure of the platelet count and the mean platelet volume (MPV). An analysis of 5000 unselected blood specimens showed an inverse relationship between the number of circulating platelets and their MPV.
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Platelet Economy (Platelet Survival and Turnover)*
British Journal of Haematology, 1966Investigators studying blood platelet survival and turnover have used the term ‘thrombo‐kinetics’ to describe the subject, by analogy with the usages of thermodynamics. Inasmuch as these phenomena reflect the interactions and hazards which the platelets encounter while discharging their function in the circulation, we prefer the term ‘platelet economy’
J F, Mustard, H C, Rowsell, E A, Murphy
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Platelet substitutes and novel platelet products
Expert Opinion on Investigational Drugs, 2000Despite many advances in the safety, processing and storage of conventional 22 degrees C liquid-stored allogeneic platelet concentrates, there are still significant drawbacks to standard platelet concentrates used in transfusions for patients with thrombocytopenia.
D H, Lee, M A, Blajchman
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Platelet Aggregometry and Anti-Platelet Isoantibodies
Haemostasis, 2009102 sera from polytransfused patients have been screened in platelet aggregometry. Anti-human platelet isoantibodies, tested against ‘responsive’ human platelets in PRP, give in the aggregometer a decrease in optical density recorded as a sigmoidal curve.
E, Pogliani +5 more
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