Results 251 to 260 of about 841,367 (303)

Platelet Formation, Platelet Density and Platelet Ageing

1990
Microscopic examination of both platelets and megakaryocytes shows them to vary widely in size and ultrastructure. This structural diversity was noted by early investigators (Bunting 1909) and interest in its origin and significance has continued to the present day.
K. G. Chamberlain, M. Tong, D. G. Penington   +2 more
openaire   +1 more source

PLATELETS AS IMMUNOGENS

Vox Sanguinis, 1992
An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
openaire   +3 more sources

Platelet dose for prophylactic platelet transfusions

Expert Review of Hematology, 2010
Although guidelines exist to deal with some aspects of platelet transfusion practice, many important clinical issues have not been addressed in large randomized controlled trials (RCTs). Slichter et al. conducted a RCT of prophylactic platelet transfusions to determine the effects of the dose of platelets on clinical signs of bleeding, the use of ...
Joan, Cid, Miguel, Lozano
openaire   +2 more sources

Platelet Activity in Washed Platelet Concentrates

Anesthesia & Analgesia, 2004
Life-threatening anaphylaxis or febrile nonhemolytic transfusion reactions after transfusion of platelet concentrates (PCs) is a serious clinical problem caused by the sensitizing of recipients to plasma components, such as immunoglobulin A, or by cytokines. There is a possible indication for washing of PCs in these thrombocytopenic patients.
Schoenfeld H, Muhm M, Doepfmer U, Exadaktylos A, Radtke H   +4 more
openaire   +3 more sources

Platelet aggregation and platelet-inhibiting drugs

Neurochemical Pathology, 1987
Platelet function may cause a progression of central gray matter damage after cerebrospinal hemorrhage or trauma because of the thrombotic occlusion of injured vessels or a vasospasm induced by extravasated blood. It has therefore been suggested that antiplatelet drugs could limit the extent of the neurological lesions produced by a spinal trauma.
openaire   +2 more sources

Platelet Count and Platelet Stickiness in Rats

Thrombosis and Haemostasis, 1971
SummaryIn rat, a transected tail vessel proved an adequate source of blood for platelet enumeration. When suspensions of rat blood in ammonium oxalate were rotated for 1 h a significant loss of platelets was observed. This platelet reduction rate (PRR), calculated as per cent of the pre-rotation count, showed individual constancy and inter-individual ...
O P, Grüner, G K, Endresen
openaire   +2 more sources

Platelets and platelet inhibitors in infective endocarditis

Current Infectious Disease Reports, 2002
The pathogenesis of infective endocarditis depends on complex interactions between the causative pathogen, plasma proteins, platelets, and vascular endothelial cells. In addition to being the main target of bacteria in the initial stage of bacterial adherence to the endocardium, platelets now appear to play an important role in antimicrobial host ...
openaire   +2 more sources

Mechanism and control of platelet-platelet interactions

Microvascular Research, 1972
Abstract With the technique of shadow-casting of whole platelets, it has been possible to observe both the very early events produced on the platelet surface by aggregating agents and what appears to be the entire process of platelet aggregation. It has been shown that a variety of aggregating agents and conditions such as ADP, thrombin, collagen ...
François M. Booyse, Thomas P. Hoveke, Donna Kisieleski, Max E. Rafelson   +3 more
openaire   +1 more source

Platelet aggregation by platelet-clumping substance

Thrombosis Research, 1974
Abstract The platelet-clumping substance isolated from rabbit plasma by the authors aggregated washed rabbit platelets, while ADP did not. The presence of AMP or adenosine did not inhibit the appearance of platelet aggregation induced by the clumping substance.
H, Yamazaki, T, Sano, T, Shimamoto, T, Shimamoto   +3 more
openaire   +2 more sources

The Platelet Count and Mean Platelet Volume

British Journal of Haematology, 1981
Summary. The Coulter Model S‐Plus Counter provides a measure of the platelet count and the mean platelet volume (MPV). An analysis of 5000 unselected blood specimens showed an inverse relationship between the number of circulating platelets and their MPV.
openaire   +2 more sources