Results 251 to 260 of about 1,180,803 (314)

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio as Biomarkers for the Prediction of Activity and Recurrence of Hepatic Echinococcosis: A Retrospective Observational Cohort Study. [PDF]

Cureus
Al-Jawdah K, Mohalab Yaseen K, Hamdi Hussein G.   +2 more
europepmc   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Innovations in Platelet Cryopreservation: Evaluation of DMSO-Free Controlled-Rate Freezing and the Role of a Deep Eutectic Solvent as an Additional Cryoprotective Agent. [PDF]

Int J Mol Sci
Befekadu R, Bosnjak N, Uhlin M, Wikman A, Sandgren P.   +4 more
europepmc   +1 more source

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Platelets as central hubs of inflammation. [PDF]

Front Immunol
Bo Y, Zhao F.
europepmc   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study. [PDF]

Discov Oncol
He X, Zhang Y, Yi Z, Zhao X, Shi Y, Hua S.   +5 more
europepmc   +1 more source

Oral Celastrol Micelles Forming High‐Density Lipoprotein Corona Targeting Hepatocytes for MASLD Treatment

Advanced Science, EarlyView.
Upon oral administration, OPDEA‐PCL/CEL micelles passed through the stomach acid intact, then quickly penetrated the intestinal mucus and transported into circulation, where they captured HDL to form a protein corona and target hepatocyte SR‐B1 receptors, inducing endocytosis.
Chang Xu, Haoru Zhu, Kai Wang, Haitao Hu, Xuyong Wei, Dongdong Xu, Jing Zhang, Yanpeng Liu, Jun Chen, Youqing Shen, Nasha Qiu, Xiao Xu   +11 more
wiley   +1 more source

Identification of salvianolic acid A as an ADP receptor-selective and Gq/IP₃ pathway-mediated anti-platelet component in Qishen Yiqi. [PDF]

Chin Med
Dang W, Chen L, Shang Q, Zhao T, Chang L, Wang T, Lyu M, Tian X, Guo H, He S, Hu J, Zhang P, Zhu Y.   +12 more
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source